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Old 18-03-2018, 12:41 PM   #781
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Default If using highly dangerous cancer-causing radiation to diagnose and tre

Intelligent Cancer Treatment

If using highly dangerous cancer-causing radiation to diagnose and treat cancer is the best modern medicine can come up with then we should feel sorry for humans as well as the practice of modern medicine. Oncologists are good at cutting, burning and poisoning cancer with surgery, radiation, and drugs, but they fail to treat the cause of cancer.

They try to help but usually do more harm than good. Oncologists focus on naming cancer based on geography and body location. They pay little to no attention to the cause of the cancer. Obviously, there are mechanisms and pathways that lead to cancer, but traditional doctors are simply not interested in helping patients and their families avoid cancer or its reoccurrence. They prove this by treating and diagnosing cancer in the most dangerous ways possible, never telling their patients all the good things they can do for themselves.

Instead of asking what cancer and what chemo agent should be used the intelligent thing to do is diagnose WHY the cancer has occurred. What are the underlying causes that lead to cancer and other illnesses? Modern medicine approaches illness like a mechanic trying to diagnose what’s wrong with your car by listening to the noises it makes and never looking inside to see what’s going on. However, it is easy to look under the hood.

Even without a battery of expensive medical tests we can profile the basic physiological parameters of each patient (one can do this at home no doctor needed) thus giving us methods for identifying the conditions in which a person’s cancer thrives. It is just too difficult for doctors to use simple pH measuring strips to get an idea of a patients overall internal physical condition and even more difficult for them to count how fast a person is breathing.

In the 1920s Dr. Otto Warburg carried out a great deal of work on cancer’s basic mechanism and was awarded a Nobel Prize in 1932. Warburg’s work clearly demonstrated that cancer is, fundamentally, a relatively simple disease where cell oxygen levels fall to a level sufficiently low enough for the cell to change in nature. Without a dependable supply of oxygen, the cells in our bodies cannot function properly. Nutrients in our diets must have oxygen present to convert their potential energy into usable energy. For new cells to be formed, hundreds of amino acids must link together using oxygen as the source of their energy.

If we work at changing conditions that we can easily measure, we have a chance of healing ourselves of cancer; without cutting, burning and poisoning with surgery, radiation and nasty chemotherapy (which is the process of poisoning people in clear daylight). Better idea would be to bomb the cancer to smithereens with Oxygen!

Read More:
http://drsircus.com/general/intellig...66492f2d935b46

E-books:
http://drsircus.com/product-category/ebooks/

Treating Cancer:
http://drsircus.com/?s=cancer+compendium

Surviving Cancer:
http://drsircus.com/?s=surviving+Cancer

Dr. Sircus has a special offer on his cancer compendium (Surviving Cancer) at the moment, 3000+ page pdf for 78 USD (reduced from 249 USD) - Only for those who wish to take control of their own health!

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Old 18-03-2018, 01:32 PM   #782
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How Cancer Has Been Forced On The People Since The 1950s - David Icke



David Icke: One of the Most Corrupt Industries on Earth - the Cancer Industry

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Old 28-04-2018, 06:51 PM   #783
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Fast cure for cancer - no drugs/ no radiation/ no chemicals/ no hospitals/ no doctors/ no surgery.
Simply through cell correction via DNA memory.

This has been available for 20 years!

And people are still dying from cancer and having chemotherapy???


https://forum.davidicke.com/showthread.php?t=321633

Who has tried Monoatomic Gold for cancer?

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Old 30-04-2018, 12:51 AM   #784
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Default A potentially targetable Achilles' heel of cancer

Many of the mutations in the DNA of a cancer cell will lead to changes in the proteins expressed on it's surface and these can be recognised by the immune system as 'foreign.' As a consequence, such specific neoantigens can be targeted by different types of immunotherapies, which will attack cancer cells but shouldn't have an effect on any healthy cells.

In this trial https://clinicaltrials.gov/ct2/show/NCT03412877 Dr. Rosenberg and his team at the US NCI will firstly look for every individuals own neoantigens. Once found they then genetic modify their T-cells to express a receptor (TCR) in order to target these. They then get infused into the patient and it's hoped they will cause the reduction and destruction of all tumours.
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?
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Old 07-05-2018, 07:14 AM   #785
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The immune system will only identify something as "foreign" if it has been introduced.

"Attacking" the body or parts thereof is not conducive to good health.

Only by nurture and assistance of the body can good health be forthcoming.
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Old 07-05-2018, 10:16 AM   #786
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KILL CANCER CELLS in 42 Days with BREUSS DIET. Drink Vegetables Juice to CURE CANCER NATURALLY
https://www.youtube.com/watch?v=LiETQpCFbzM

https://www.amazon.com/Breuss-Cancer...ARudolf+Breuss
His book
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Old 07-05-2018, 05:08 PM   #787
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The immune system will only identify something as "foreign" if it has been introduced.

"Attacking" the body or parts thereof is not conducive to good health.

Only by nurture and assistance of the body can good health be forthcoming.
Peptides (short chains of amino acids) are normally displayed on the outside of cells. As cancer cells have multiple mutations in their DNA then some of these alter the sequence of the peptides, converting them from normal antigens into neoantigens. The new (neo)antigens look ''foreign'' to the immune system and cause it to mount a response.

Two of 12 patients with metastatic gastrointestinal cancers treated at the US NCI with tumour-infiltrating lymphocytes (TILs) that targeted mainly a single expressed neoantigen demonstrated objective clinical responses. The first patient, whose metastatic bile-duct cancer, exhibited disease stabilisation for about 1 year following the transfer of 42 billion TILs that were retrospectively determined to contain approximately 25% of a T-cell subtype (CD4+) which targeted a mutation in a tumour suppressor (ERBB2IP). Upon disease progression, the patient was treated with a second infusion that contained 126 billion T-cells, approximately 95% of which recognised the ERBB2IP neoantigen. This patient then experienced a near-complete regression of all metastatic disease now lasting for over 2.5 years http://science.sciencemag.org/content/344/6184/641.long

The second patient https://www.nejm.org/doi/10.1056/NEJMoa1609279 who responded to TIL therapy had metastatic colorectal cancer and their T-cells recognised a certain mutation in KRAS (G12D). The transfer of 148 billion T-cells, approximately 75% of which targeted this, was associated with the regression of all seven metastatic lung lesions. However, a single lung lesion progressed 9 months after the transfer of these TILs. This lesion was surgically removed, and the patient remains clinically disease free https://www.today.com/health/experim...cancer-t107772 Genomic analysis of the progressing lesion revealed the presence of cancer cells that had undergone immunoselection and could no longer be recognition by the T-cells.

Nevertheless, the tumour regressions observed following the administration of highly enriched populations neoantigen reactive T-cells to these two patients provided evidence that T-cells targeting these can mediate substantial clinical benefit to patients with metastatic cancer. Moreover, these responses occurred in the absence of any major toxicities.

In the near future targeting more cancer specific antigens like phosphopeptides (these arise from inappropriate phosphate groups being added to various proteins before they get made into antigens) should improve the depth (tumour shrinkage) and duration of any response. You can also make major improvements (some of which I will talk about in a future post) to TCR T-cells (which are being tested in the trial I linked to) thanks to advances in synthetic biology https://www.cell.com/cell/fulltext/S...674(17)30064-8
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 07-05-2018, 07:04 PM   #788
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It's perfectly natural for the immune system to reject toxic shite. It is exactly the point I was making.

All cancer requires is treatment by one or more proven cures, There are many to choose from, including baking soda, cannabis, monoatomic gold, etc etc.

People need to wake up and take responsibility for their own and loved ones health, and stop handing it over to corrupt and disinformed/misinformed third parties who have ulterior motives for preventing cures.

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Old 26-07-2018, 08:00 PM   #789
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A new trial https://clinicaltrials.gov/ct2/show/NCT03552718 is testing a personalised yeast-based vaccine in those who have completed potentially curative therapy for their cancer and who would otherwise be entered into active surveillance for potential recurrent disease. There is limited preclinical evidence that the vector used could decrease the number and function of Tregs https://www.sciencedirect.com/scienc...64410X11006566 These cells have an immune suppressive function and help to inhibit the recognition and clearance of cancer cells by the immune system.
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?
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Old 26-07-2018, 10:08 PM   #790
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Dumbcritic posts the exact same comments on this forum that accounts that promote a fraudulent CBD oil site on other platforms do. The site name was banned on this forum after an attempt to promote it here: ***********.com

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Old 26-07-2018, 11:00 PM   #791
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Dumbcritic posts the exact same comments on this forum that accounts that promote a fraudulent CBD oil site on other platforms do. The site name was banned on this forum after an attempt to promote it here: ***********.com
I'm not that person. Epidiolex is the only proven CBD based drug. The rest are a waste of money.
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 27-07-2018, 12:56 AM   #792
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I'm not that person. Epidiolex is the only proven CBD based drug. The rest are a waste of money.
Why do you post the exact same quotes these fraud accounts do then?
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Old 02-08-2018, 12:47 PM   #793
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How is Ziopharm doing today, loser? $ZIOP
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Old 02-08-2018, 10:01 PM   #794
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Why do you post the exact same quotes these fraud accounts do then?
Like?
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?
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Old 02-08-2018, 10:14 PM   #795
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How is Ziopharm doing today, loser? $ZIOP
Or if you think a secondary will happen, you'd take up a short position.

Either way the company has enrolled the first patient with rGBM in the combo trial http://ir.ziopharm.com/news-releases...ial-evaluating and just listed the 3rd Gen CAR-T one https://clinicaltrials.gov/ct2/show/NCT03579888 The latter should reduce production time and added mbIL15 will likely enhance persistence and antitumour activity of the cells http://www.pnas.org/content/113/48/E7788.long

I'm also hoping the neoantigen reactive TCR trial at the NCI will open before the end of the year too https://www.cell.com/molecular-thera...016(16)30375-6
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 03-08-2018, 02:06 AM   #796
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Can you believe this guy literally shilling for pharmaceutical investments he likes on our forum???
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Old 03-08-2018, 05:35 PM   #797
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Can you believe this guy literally shilling for pharmaceutical investments he likes on our forum???
So instead of me promoting a fraudulent CBD oil site I'm now a shill. I wonder what you will accuse me of next week?!

I could play the same game and insinuate you have been taking money or made deals with alt med woo meisters to push their crap. But that would be rather silly. All I will say is that so-called alt med kills https://sciencebasedmedicine.org/alt...ntary-edition/

This is unlike CAR-T therapies which have been proven to work in CD19+ malignancies and are now FDA https://www.gilead.com/news/press-re...stemic-therapy https://www.novartis.com/news/media-...-cell-lymphoma and EMA http://www.ema.europa.eu/ema/index.j...01ac058004d5c1 approved.

Ziopharm have long-term follow-up data for the 1st Gen version https://ziopharm.com/wp-content/uplo...llowupcd19.pdf and it's very likely the 3rd Gen will have improved efficacy based on the preclinical data I cited. So there is good reason why I linked to the trial.

As for the vaccine (post #789) I know others have shown these reduce the risk of relapse https://www.nature.com/articles/nature23003 https://www.nature.com/articles/nature22991
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 18-08-2018, 10:48 PM   #798
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A new trial https://clinicaltrials.gov/ct2/show/NCT03552718 is testing a personalised yeast-based vaccine in those who have completed potentially curative therapy for their cancer and who would otherwise be entered into active surveillance for potential recurrent disease. There is limited preclinical evidence that the vector used could decrease the number and function of Tregs https://www.sciencedirect.com/scienc...64410X11006566 These cells have an immune suppressive function and help to inhibit the recognition and clearance of cancer cells by the immune system.
Another new vaccine trial https://clinicaltrials.gov/ct2/show/NCT03633110 It is being tested in three different parts. The first will use it as a monotherapy in patients with no evidence of disease, but with a high risk of relapse. The second will combine it with Opdivo in those with advanced or metastatic disease. The third will test it as a monotherapy again, but in a relapsed or refractory setting.

The company behind this uses their own discovery platform (ATLAS). Once the mutations have been identified, they clone and express these into E. coli strains (+/- listeriolysin O to enable presentation via both MHC class I or class II). Then for each patient, these get co-cultured with their APCs and then T-cells are added and incubated overnight. After this, antigen-specific responses are detected by comparing cytokine production in response to each of these against a non-immunogenic control protein.

This has been employed in the context of certain infectious pathogens, including HSV-2 https://www.sciencedirect.com/scienc...64410X16307952 https://academic.oup.com/jid/article/215/6/856/2964581
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 25-08-2018, 03:43 PM   #799
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Another new vaccine trial https://clinicaltrials.gov/ct2/show/NCT03633110 It is being tested in three different parts. The first will use it as a monotherapy in patients with no evidence of disease, but with a high risk of relapse. The second will combine it with Opdivo in those with advanced or metastatic disease. The third will test it as a monotherapy again, but in a relapsed or refractory setting.

The company behind this uses their own discovery platform (ATLAS). Once the mutations have been identified, they clone and express these into E. coli strains (+/- listeriolysin O to enable presentation via both MHC class I or class II). Then for each patient, these get co-cultured with their APCs and then T-cells are added and incubated overnight. After this, antigen-specific responses are detected by comparing cytokine production in response to each of these against a non-immunogenic control protein.

This has been employed in the context of certain infectious pathogens, including HSV-2 https://www.sciencedirect.com/scienc...64410X16307952 https://academic.oup.com/jid/article/215/6/856/2964581
Yet another neoantigen vaccine trial https://clinicaltrials.gov/ct2/show/NCT03639714

They will be using a heterologous prime-boost regime. A chimpanzee adenoviral vector is used as the prime and then it's boosted by synthetic self-amplifying mRNA. This has been shown to induce greater numbers of antigen specific T-cells and increases the quality of response by involving multiple subsets and cytokine profiles. With anti-CTLA4 in preclinical studies they have shown extremely high and sustained T-cell responses. This compares to T-cell numbers observed in successful ACT (adoptive cell transfer) http://cancerres.aacrjournals.org/co...Supplement/724

In addition to this their in silico selection methods should work better than others (~9X improvement over other tools used in this process) http://cancerres.aacrjournals.org/co...upplement/5722

A number of studies suggest that levels of approximately 10,000 antigen specific T-cells per milliliter of blood measured in patients four weeks post-infusion indicate clinical benefit.

In this preclinical study they constructed the vaccine and encoding six different viral antigens.

This is data showing the levels of antigen specific T-cells in response to the vaccine without the addition of anti-CTLA4


With the addition of anti-CTLA4


This is a comparison of the numbers of T-cells induced by the vaccine plus anti-CTLA4 compared to those who responded (tumour shrinkage) after receiving adoptive T-cell therapies

(Refs: 1 http://ascopubs.org/doi/full/10.1200/JCO.2014.58.9093 2 https://www.thelancet.com/journals/l...403-3/fulltext 3 http://clincancerres.aacrjournals.org/content/21/5/1019 )

High T-cell titers persist for at least six months


This is a comparison of the duration of T-cells observed for the vaccine plus anti-CTLA4 to an approved CD19 targeting adoptive T-cell therapy

(Ref: 1 https://www.nejm.org/doi/full/10.1056/NEJMoa1707447 )
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 02-10-2018, 10:39 PM   #800
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Some early data from one trial https://clinicaltrials.gov/ct2/show/NCT03056339 (currently recruiting) that is very promising. It uses off-the-shelf NK cells from umbilical and cord blood that are engineered to target CD19 in certain cancers. Of the nine patients, six have had a CR (the disappearance of all signs of cancer). No neurotoxicity or cytokine release syndrome has happened so far.

This is an overview with more info on them


Here are some PET scans



The persistence of the cells seems durable, so far


Resistance to therapy is usually down to lack of expansion, persistence, loss of the target antigen and/or poor trafficking. To overcome the first two they add a single costim (CD28) and IL-15. Both help with expansion and persistence. Adding a second costim (4-1BB) http://cancerres.aacrjournals.org/co...upplement/4702 and IL-21 https://journals.plos.org/plosone/ar...l.pone.0030264 would further enhance efficacy. Loss of antigen can be dealt with by targeting two or three of these at a time and making sure all binders are fully human.

Using certain cytokines cocktails ex vivo can improve functionality https://www.sciencedirect.com/scienc...83879114000226 and with added small molecule inhibitors they become more cytotoxic http://cancerres.aacrjournals.org/co...7/20/5664.long and resistant to the immunosuppressive effects of the cancer https://journals.plos.org/plosone/ar...l.pone.0191358
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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