rick simpson- building more than a cure for cancer

[supertzar]

So, Dumb - if I wanted to invest in marijuana penny stocks what would be a good choice? Like small caps, you know?

[supertzar]

AmeriCann sounds hot ...a million bucks for a 150,000 square foot facility. Whoah! That's a lot of meds. I think their stock is going to go up.

http://www.nbc12.com/story/35588849/...nabis-producer

DENVER, CO / ACCESSWIRE / June 5, 2017 / AmeriCann, Inc. (OTCQX: ACAN), an Agricultural-Technology company that is developing the next generation of sustainable, state-of-the-art medical cannabis cultivation properties, announced today it has completed a very successful three-year partnership with a licensed Colorado cannabis producer that has resulted in exceptional returns to the company.

In 2014, AmeriCann contributed $1,000,000 in secured funding for the final design and construction of a 15,000 square foot state-of-art cultivation and processing facility in Denver, CO. AmeriCann’s Preferred Partner, 4900 Jackson, LLC, has been a licensed medical cannabis producer in Colorado since 2010.

[supertzar]

Finally figured out why he has been trolling the board with this shit all these years. I knew there was something in it for him but couldn't understand why he was posting both pro and anti-Cannabis messages under different aliases during the same time frame.

[supertzar]

Proof he is not just a troll but a scammer trying to separate patients from their money: All you have to do to find a bunch of his aliases is start googling some of his more "copy-and-pasty" quotes. In the comments section of Cannabis articles on many, many different sites you'll find a number of different aliases posting the exact same things he posted here for years word for word. Comments by these aliases promote a fake CBD oil site that was being promoted in a thread on this forum recently.

[dumbcritic]

Originally Posted by supertzar

I'm guessing 30% is considered significant. You are going to have to keep backing the fuck up on everything you have said for the rest of your life.

It seems GW Pharma did present a poster at ASCO https://meetinglibrary.asco.org/record/153300/abstract and another at the SNO conference https://academic.oup.com/neuro-oncol...6/vi13/4590341 Yet they gave no PR before, during or after these events. No posters have been uploaded to their site either. This should tell you all you need to know. It might have a place in the CUSP9 protocol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226667/ which is being tested https://clinicaltrials.gov/ct2/show/NCT02770378

ZioPharm have done the exact opposite. The SNO poster http://www.ziopharm.com/content/02-p...ladultrgbm.pdf shows mOS is still the same and in the four patients who used under 10mg of Dexamethasone over the 14 days of treatment then survival was 100% (10-24+ months ongoing). They even had an update call https://edge.media-server.com/m6/p/o3n5qm53 Now a trial is happening in pediatric patients https://clinicaltrials.gov/ct2/show/NCT03330197 and two others will be the pivotal Phase III and combo one using it with a checkpoint inhibitor (anti-pd1). Sadly the other combo (with ''off-the-shelf'' NK cells) had to be scrapped due to lack of funds.

Combination treatments will be needed to hopefully turn rGBM and certain other cancers into chronic diseases. In the video below Prof. Seyfried goes into detail about the ketogemic diet and DON. This could be used with ketone supplements, hyperbaric oxygen therapy, 2-Deoxy-D-glucose, perillyl alcohol https://www.thieme-connect.com/produ...s-0037-1605588 https://www.spandidos-publications.c...2/ol.2017.7362 http://ar.iiarjournals.org/content/33/12/5625.long the Optune device https://www.optune.com/hcp/clinical-data/efficacy and so on.

[supertzar]

It's back.

[dumbcritic]

The FDA adcom with GW Pharma will take place on the 19th of this month. They will discuss the single NDA for Epidiolex in two indications (Dravet syndrome & Lennox-Gastaut syndrome). If all goes well then DEA reschedulling will happen in 3Q (they company hopes it will be placed into Schedule 4) and the launch should be 4Q.

The EMA meeting will take place 1Q 2019. As for GWP42006 (CBDV) then it failed in a Phase IIa trial https://globenewswire.com/news-relea...-GWP42006.html

[dumbcritic]

Here https://academic.oup.com/annonc/arti...88.005/4109591 is a study that was presented at last years ESMO Congress.

It was retrospective, observational and conducted by researchers in Israel. They collected data from 140 patients with either advanced melanoma, non-small cell lung cancer or renal cell carcinoma. Eighty-nine received Opdivo alone, and 51 received cannabis in combination with the drug. They showed that 33% of the lung cancer patients treated solely with Opdivo responded (tumour shrinkage) to the drug, compared to only ~17% of those treated with the drug and cannabis concurrently. Among the melanoma and renal cancer patients, ~43% responded to the drug-only treatment, while only 10% of those treated with both responded. There wasn't any significant effects on either progression-free survival or overall survival rates.

So based on this data it would be very unwise to combine RSO/FECO/cannabinoid based drugs with different immunotherapies.

Opdivo is a monoclonal antibody which targets PD-1 on T-cells. Broadly speaking these cells can be grouped into various subsets (e.g., Th1, Th2, Th9, etc) based on their functions, cytokine profiles and so on. T helper type 1 (Th1) cells are required for host defence against intracellular viral or bacterial pathogens and cancer.

We know that THC given to mice triggers a shift from Th1 to Th2 https://www.nature.com/articles/nature03389 http://jpet.aspetjournals.org/content/319/1/269.long https://link.springer.com/article/10...481-008-9126-2 and this could be one of the reasons why the response rates were lower. Another could be that it induces the mobilisation of myeloid-derived suppressor cells (MDSCs) https://onlinelibrary.wiley.com/doi/.../eji.201040667 and they then traffic to the tumour microenviromemt. Once there they inhibit CD8+ T-cells through the expression of nitric oxide synthase 2 and arginase http://www.cell.com/trends/immunolog...906(03)00132-7 (they have other negative effects as well). Or it interferes with tumour surveillance by the immune system http://www.jimmunol.org/content/165/1/373.long http://www.jimmunol.org/content/174/6/3281.long CBD and other molecules in the plant interact with immune cells too.

Targeting different TLRs https://jitc.biomedcentral.com/artic...2051-1426-2-12 or using small molecules like X4P-001 http://www.x4pharma.com/wp-content/u...ster_Final.pdf http://www.x4pharma.com/wp-content/u...0117_Final.pdf Entinostat http://www.syndax.com/wp-content/upl...-SITC-2017.pdf http://www.syndax.com/wp-content/upl...-SITC-2017.pdf INCB001158 https://www.calithera.com/wp-content...2017-FINAL.pdf and many other drugs which target MDSCs show promise in a range of cancers.

You can also use different monoclonal antibodies http://clincancerres.aacrjournals.or...21/5/1127.long or other therapies https://onlinelibrary.wiley.com/doi/.../eji.201445132 to shift the tumour microenvironment from the Th2 type to Th1 immunity.

[supertzar]

What are you doing here? This board is not for scammer scumbags who try to sell fake CBD oil. You post the exact same copy&pastes as accounts around the web who promote a fake Cannabis oil site.

[dumbcritic]

Originally Posted by supertzar

What are you doing here? This board is not for scammer scumbags who try to sell fake CBD oil. You post the exact same copy&pastes as accounts around the web who promote a fake Cannabis oil site.

Not this crap again. I've said before it's never been proven to work for any type of illness or condition. Therefore making or buying the stuff is a waste of time and money.

The real scammers are Rick Simpson et al. He sells (e)books, has a donate button on his site, ask for large sums of money for tours https://www.icmag.com/ic/showpost.ph...06&postcount=3 and much more besides.

[supertzar]

Originally Posted by dumbcritic

Not this crap again. As I've said before it's never been proven to work for any type of illness or condition. Therefore making or buying the stuff is a waste of time and money.

You got destroyed for years on this thread. Everything you said was wrong. Now screw off, scammer.

[dumbcritic]

The FDA internal review https://www.fda.gov/downloads/Adviso.../UCM604736.pdf for Epidiolex as an adjunctive treatment was mostly positive. Dr. Buracchio (team leader) stated: ''The statistically significant and clinically meaningful results from these three studies provide substantial evidence of the effectiveness of CBD for the treatment of seizures associated with LGS and DS.''

Now the adcom 13-to-0 (in favour) vote sets the stage for formal approval on the 27th of June.

[supertzar]

Originally Posted by dumbcritic

The FDA internal review https://www.fda.gov/downloads/Adviso.../UCM604736.pdf for Epidiolex as an adjunctive treatment was mostly positive. Dr. Buracchio (team leader) stated: ''The statistically significant and clinically meaningful results from these three studies provide substantial evidence of the effectiveness of CBD for the treatment of seizures associated with LGS and DS.''

Now the adcom 13-to-0 (in favour) vote sets the stage for formal approval on the 27th of June.

Damn, so you were wrong as fuck. Should have listened way back when.

[the nine]

Originally Posted by dumbcritic

Not this crap again. I've said before it's never been proven to work for any type of illness or condition. Therefore making or buying the stuff is a waste of time and money.

The real scammers are Rick Simpson et al. He sells (e)books, has a donate button on his site, ask for large sums of money for tours https://www.icmag.com/ic/showpost.ph...06&postcount=3 and much more besides.

I know 1 actual person who has had full remission from cancer without any medical treatment (no chemo or radio therapy)
The guy is in his late 60's and nearly 2 years later is still cancer free!!
Using only cannabis oil.

So it's is possible and certainly a lot cheaper than the chemo scam that 80% of doctors would refuse if they contracted cancer

[dumbcritic]

Originally Posted by supertzar

Damn, so you were wrong as fuck. Should have listened way back when.

I'm pretty sure in previous posts I said the data for the drug was encouraging and why you shouldn't compare it to RSO/FECO.

Keep in mind that the trials didn't show that the drug had anti-seizure activity as a single-agent, only that, when added with other meds, it could further decrease seizure frequency. So not the miracle treatment you seem to think it is. In Dravet Syndrome the median seizure reduction was ~40%. For low dose Fenfluramine (ZX008) then ~72% was achieved (lower p-value and used in sicker patients). This data comes from the first PhIII trial. We'll have to wait until Q2 for the second readout. Another PhIII is ongoing in LGS.

During GW Pharma's conference call the CEO said that based on currently available data Epidiolex is unlikely to proceed into a PhIIb trial for infantile spasms.

[dumbcritic]

Originally Posted by the nine

I know 1 actual person who has had full remission from cancer without any medical treatment (no chemo or radio therapy)
The guy is in his late 60's and nearly 2 years later is still cancer free!!
Using only cannabis oil.

I'm glad he's still in remission. Was surgery preformed? It's still the most curative treatment there is https://sciencebasedmedicine.org/chris-beat-cancer/ If not then spontaneous regressions and remissions have been noted http://autopsyandcasereports.org/art...2/acr.2017.025 https://www.lungcancerjournal.info/a...716-2/fulltext (some of the mechanisms are known https://forum.davidicke.com/showpost...75&postcount=6)

Originally Posted by the nine

So it's is possible and certainly a lot cheaper than the chemo scam that 80% of doctors would refuse if they contracted cancer

Many of the chemo drugs used today are long off patent and relatively cheap. Most doctors would undergo treatment with these https://anaximperator.wordpress.com/...on-themselves/

[the nine]

Originally Posted by dumbcritic

I'm glad he's still in remission. Was surgery preformed? It's still the most curative treatment there is https://sciencebasedmedicine.org/chris-beat-cancer/ If not then spontaneous regressions and remissions have been noted http://autopsyandcasereports.org/art...2/acr.2017.025 https://www.lungcancerjournal.info/a...716-2/fulltext (some of the mechanisms are known https://forum.davidicke.com/showpost...75&postcount=6)



Many of the chemo drugs used today are long off patent and relatively cheap. Most doctors would undergo treatment with these https://anaximperator.wordpress.com/...on-themselves/

No surgery what so ever, not even prescription drugs!
They fucked the medical world off and beat cancer themselves.
From my own experience, every person in my family that has contracted cancer has died slowly and painfully until they are being euthanised via morphine.

You would have thought this story of one mans complete recovery from this aggressive cancer would be news worthy eh?
It never even made the local news.. it seems the MSM are not interested in cancer cures if they are no celebrating some hospital or doctor.. weird eh?

[supertzar]

Originally Posted by dumbcritic

I'm pretty sure in previous posts I said the data for the drug was encouraging and why you shouldn't compare it to RSO/FECO.

Keep in mind that the trials didn't show that the drug had anti-seizure activity as a single-agent, only that, when added with other meds, it could further decrease seizure frequency. So not the miracle treatment you seem to think it is. In Dravet Syndrome the median seizure reduction was ~40%. For low dose Fenfluramine (ZX008) then ~72% was achieved (lower p-value and used in sicker patients). This data comes from the first PhIII trial. We'll have to wait until Q2 for the second readout. Another PhIII is ongoing in LGS.

During GW Pharma's conference call the CEO said that based on currently available data Epidiolex is unlikely to proceed into a PhIIb trial for infantile spasms.

You have said many things, almost all of which are untrue. One thing you said is one medicinal compound per plant is the rule. Do you think reality cares about your rule? You also said Cannabis can't work as medicine because there is no clinical data to support it. That is a fallacy. It shows a complete lack of scientific understanding not to mention common sense. You said that specifically about epilepsy even.

[dumbcritic]

Originally Posted by the nine

No surgery what so ever, not even prescription drugs!
They fucked the medical world off and beat cancer themselves.
From my own experience, every person in my family that has contracted cancer has died slowly and painfully until they are being euthanised via morphine.

You would have thought this story of one mans complete recovery from this aggressive cancer would be news worthy eh?
It never even made the local news.. it seems the MSM are not interested in cancer cures if they are no celebrating some hospital or doctor.. weird eh?

It's a shame no case report was published as that could have provided additional clues as to why this happened and lead to new and better treatments.

I know one company has raised $40 million. They look for IgG+ memory B-cells from "elite" disease responders, screen them to find desired properties, sequence those and in turn create recombinant antibodies. The cash will be used to bring five programs (melanoma, non-small cell lung, prostate, gastric and chronic myeloid leukaemia) into human testing sometime in 2020.

A second has raised $125 million. They too will be creating recombinant antibodies, but these will be targeting known ('public') antigens https://www.sciencedirect.com/scienc...21661617305016 The first trial should be underway next year and in multiple solid tumours (breast, lung, colon and so on).

A third is using a different approach https://www.dailymail.co.uk/health/a...ls-tested.html and there is some early human data https://www.sciencedirect.com/scienc...05844017316936

Using a vaccine for the first two should improve efficacy. We know from both preclinical and clinical data that these generate a polyclonal (i.e. different kinds of antibodies) rather than a monoclonal response increasing the chance that cancer cells carrying the target antigen will be killed. The adjuvant helps increase the size of the immune response as well. Then there is the potential for immune memory which may mean the patient wouldn't need IV infusions every 1-3 weeks https://link.springer.com/article/10...549-006-9469-4 https://bmccancer.biomedcentral.com/...885-017-3098-7 https://www.ncbi.nlm.nih.gov/pubmed/20092022