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Old 02-12-2017, 08:25 AM   #761
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Absolute nonsense and disinformation, dc.
Which parts and nonsense and which disinformation? Why are they this?

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The truth speaks for itself - sodium bicarbonate must never be taken before, with or after a meal - that fact is made quite clear regardless of which practitioner website you go to.
Read the first part again. It's basic chemistry and physiology.

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Evidence against Tullio Simoncini was manufactured purposely by big pharma.
Why would they do this? Do you have any proof?

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These are all well known facts.
Citations needed.

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Very sorry to have totally destroyed your claims -
Never mind old chap. Chin up, You can't win them all (or in your case, any).
Better luck next time, what?
What indeed?!?
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''Chlorine is a deadly poison gas employed on European battlefields in World War I. Sodium is a corrosive metal which burns upon contact with water. Together they make a placid and unpoisonous material, table salt. Why each of these substances has the properties it does is a subject called chemistry'' - Carl Sagan

Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 03-12-2017, 09:38 AM   #762
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Looks like someone is also magnesium deficient, does it not, dc?
I would therefore recommend you follow Dr. Sircus magnesium oral and transdermal guidelines.
(Just trying to help)

How Cancer Has Been Forced On The People Since The 1950s - David Icke



Dr Tullio Simoncini explaining the simple cure for cancer



Rick Simpson: "Big Pharma Has Been burying Cancer Cures For 150 Years!"



Tullio Simoncini on the cure for cancer being suppressed by big Pharma!

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Old 03-12-2017, 11:06 AM   #763
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Sodium Bicarbonate and Cancer Treatment - Mark Sircus, Ac., OMD



Sodium Bicarbonate (Baking Soda) and Cancer

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Old 03-12-2017, 01:31 PM   #764
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Looks like someone is also magnesium deficient, does it not, dc?
I would therefore recommend you follow Dr. Sircus magnesium oral and transdermal guidelines.
(Just trying to help)

How Cancer Has Been Forced On The People Since The 1950s - David Icke



Dr Tullio Simoncini explaining the simple cure for cancer



Rick Simpson: "Big Pharma Has Been burying Cancer Cures For 150 Years!"



Tullio Simoncini on the cure for cancer being suppressed by big Pharma!

Unfortunately, given what we know today about cancer (it's hundreds of different diseases), the likelihood that a magic cure will ever be found is zero. Cancers are so diverse, heterogeneous and mutable that the approach based on looking for one is conceptually absurd.

Pharma haven't been suppressing better treatments either. The 10 year survival rate among children with acute lymphoblastic leukemia (ALL) back in the 60s was under 10%. Now it's over 90% http://www.nejm.org/doi/full/10.1056/NEJMra1400972 You can thank pioneering researchers like Dr. Freireich for some of these major advances http://www.houstonchronicle.com/news...ht-6164234.php http://www.cancerresearchuk.org/heal...stics/survival

As for Rick Simpson's cannabis oil then Dr. David Gorski said this: ''Justin Kander, cited a case report https://www.karger.com/article/fulltext/356446 that’s been going around social media as “proof” that cannabis cures cancer. This case report describes a 14-year-old girl, PK, who presented with symptoms of “weakness, shortness of breath and bruising when she was taken to the Hospital for Sick Children, Toronto, Canada, on the 10th March 2006.” She was diagnosed with acute lymphoblastic leukemia (ALL) and underwent standard chemotherapy for ALL for six months. Upon analysis, she was found to be positive for a mutation in the Philadelphia chromosome, which is found in 2-10% of pediatric ALL cases. Philadelphia chromosome-positive ALL http://umm.edu/health/medical/report...cytic-leukemia tends to have a poorer prognosis than other ALL. PK underwent a bone marrow transplant but was noted to have blast cells six months after treatment and therefore underwent aggressive chemotherapy along with a tyrosine kinase inhibitor. After more recurrences and more treatment (such as radiation therapy to the brain for a presumed, but never completely documented, infiltration of the brain by leukemia) it was stated in the case report: ''On the 4th February 2009, blood was noted in the patient’s stools and a blood cell count revealed the presence of blast cells. As a result, all treatment including the disatinib was suspended and the patient’s medical staff acknowledged failure in treating her cancer. It was charted by the patient’s hematologist/oncologist that the patient 'suffers from terminal malignant disease. She has been treated to the limits of available therapy and no further active intervention will be undertaken.' She was placed in palliative home care and told to prepare for her disease to overwhelm her body and from which she would suffer a stroke within the next 2 months.''

The family found articles on how cannabis supposedly cures cancer, and found their way to Rick Simpson, who has been featured in utterly credulous articles in High Times https://hightimes.com/read/rick-simp...p-oil-medicine and SF Weekly http://www.sfweekly.com/news/miracle...f-finding-out/ (the latter of whose editors really should have known better) as the man who can cure cancer with hemp oil, who provided her with hemp oil mixed with honey (because of the bitter taste and viscous nature of hemp oil). This was administered in daily doses. It is claimed in this case report that there was a strong correlation between increasing dose of the hemp oil and decreases in PK’s blast count (a measure of leukemia cells in the blood), but looking at Figures 1, 2, 3, and 4, I have a hard time seeing it. Figure 1 shows increasing doses of hemp oil from what was called the “chronic” strain. That’s the closest we see to decreasing blast counts correlating with hemp oil dose. By day 15, the chronic strain was gone, and PK started taking Hemp Oil #2 from an outside source. In actuality in Figure 2, we see the blast count increasing with increasing dose until day 27, when it starts falling. Figure #3 shows Hemp Oil #3 (Afghan/Thai strain) from days 44 to 49. Given that the blast count stayed the same one can’t say much about this. Then Hemp Oil #4 was tried from day 50 to day 67, and her blast counts started rising. Finally, Hemp Oil #5 was tried and PK’s blast count fell between days 69 and 78. During that time, PK suffered the psychotropic effects of the hemp oil, including euphoria, disoriented memory, and the like.

Unfortunately, PK developed gastrointestinal bleeding and bowel perforation with peritonitis on day 78 and passed away. So, basically, she lived two and a half months after being placed on hospice. The authors assert that a dose-response curve was achieved, but to my eye I really don’t see it, except perhaps at the beginning, nor do I really buy the claim that the bumps in blast counts correlate with using “lower potency” strains. They also assert because PK was treated for tumor lysis syndrome (a syndrome in which the waste products of tumor breakdown, often seen after intense chemotherapy in hematopoietic malignancies, injure organs such as the kidneys), it must mean that the hemp oil was effective.

Unfortunately, even if a mild dose-response effect was observed that would not rule out spontaneous remission. Spontaneous remission is known to occur in ALL, although it is usually temporary http://media.noetic.org/uploads/files/chapter10.pdf and spontaneous tumor lysis syndrome http://www.omjournal.org/articleDeta...Type=1&aId=463 has been reported, although it is rare. In any case, one has to wonder whether the patient’s bone marrow was petering out near the end, something that is hard to determine because almost no laboratory values other than blast counts are presented, except at the end, when she had a very low platelet count (8K; normal 150K to 450K), a low white blood cell count (1.4, normal 4.5-13.0), and severe anemia (hemoglobin 8.2; normal: 13 to 16). It wasn’t established how the diagnosis of tumor lysis syndrome was made other than that the patient had elevated urate levels. Indeed, the entire case report seemed to have been written with the belief that it was the hemp oil that accounted for the decrease in blasts. A lot of information has been left out about the patient’s clinical course. All we know is that, after being placed in hospice, she was fortunate to have her blast count fall, developed a central line infection, and was treated for tumor lysis syndrome. We can also infer that she was still having considerable issues with her gut because she was on total parenteral nutrition (being fed by vein) and had trouble when they started to try to feed her orally again.

It should also be remembered that, whether or not hemp oil was responsible for the decline in blasts (which is possible but not convincingly demonstrated by this case study) or whether it was “burnout” of the bone marrow in the terminal phase of the disease or even spontaneous remission, the patient still died. She still developed GI bleeding and a GI perforation with peritonitis and died of it only 78 days after going on hospice. There’s no way of knowing whether hemp oil prolonged her life. Probably it did not, as a two to three month survival after going into hospice after being declared terminal for leukemia is well within what is expected. In other words, this case report is mighty thin gruel indeed.

Of course, the sad story of PK and the treatment of her terminal relapsed ALL with hemp oil is probably the highest quality cancer cure testimonial out there, and unfortunately its quality is not that high at all. The rest of the anecdotes I ran into tended to be about as convincing to someone familiar with cancer as nearly all the other alternative cancer cure testimonials I’ve found; i.e., not very.''
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 05-12-2017, 01:57 PM   #765
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If you are saying big pharma has no cure for cancer, dc, then I agree wholeheartedly on that fact. Cancer is not an incurable disease, it is a multi-billion dollar industry.
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L-Arginine & Cancer

On December 15, 1991 the LA Times published a large expose about Jimmy Keller, a man dedicated to healing and experimental medicine. The government believed he was a con man, kidnapped him in Mexico, convicted him of fraud and put him in jail. Interestingly and importantly, the 1999 Nobel Prize research showed him to have been a medical genius. Almost all our understanding of arginine, a simple amino acid, comes in the years following Keller’s conviction.

Researchers around the world are serious about the use of amino acids in cancer treatment. L-arginine is the common substrate for two enzymes, arginase and nitric oxide synthase (NOS). As a precursor to nitric oxide, it is a key component of endothelial-derived relaxing factor. The endothelium is the lining inside blood vessels and arginine supplements help make more nitric oxide, which helps to relax and dilate blood vessels. The body needs higher levels of arginine when it is under conditions of stress, illness, malnutrition or injury. When these conditions are present, arginine becomes essential for healing to occur.

Dr. Joe Prendergast, a longtime expert on the power of L-arginine says, “Arginine uses the two natural pathways into the brain to promote anti-aging properties, sports performance, and boost the immune system. Because L-arginine promotes healthy blood flow, it can also benefit human sexuality.” Arginine overcomes cardiovascular issues and reverses atherosclerosis[1]. Dr. Prendergast is proud to say that all his patients through the last 17 years have managed to not succumb to any strokes, heart attacks or even to diabetes.

Arginine is used to treat conditions that improve with increased blood flow, such as chest pains, erectile dysfunction, clogged arteries, vascular disease and headaches, according to the Mayo Clinic.
Arginine is one of the 20 most common natural amino acids and this is what Keller was injecting intelligently into his cancer patients’ veins. When he administered the amino acid solution intravenously into himself first, he was astonished. “I felt a tingling in my tumor areas. They got softer. It was phenomenal.”

The LA Times article explains how, when Keller gave a patient an injection of Tumorex[2], the patient would start feeling heat in their tumor (a thermometer placed on the tumor, Keller said, showed a temperature rise of one to two degrees). There was a pulling, tingling, grabbing sensation. One patient said it felt like a thousand little fingers pulling at her tumors. People with brain tumors heard popping and cracking sounds as if fireworks were going off in their heads. Tumorex didn’t always work with everyone, but when it did, Keller said, the results could be spectacular. Within hours, patients reported, tumors began to soften and shrink, and within days they began to disappear. “On open tumors,” Keller said, “you could actually see bubbles.”

The LA Times explains further how visitors to the Keller clinic would be astounded. They’d tell stories about having seen people who would come to the clinic near death, and who, after a few days or few weeks of treatment, would be back on their feet again, walking, shopping and ready to resume their normal lives. Dr. George Eisberg, an Albuquerque family physician who testified at Keller’s trial, told of escorting a dying friend to Keller’s clinic. “I wheeled him in in a wheelchair. He couldn’t swallow.” But as soon as Keller put him on the IV drip, the patient’s chest pain subsided so much that for dinner that night he went out and ordered a lobster and a pina colada.

The Times said that, “Keller openly practiced medicine without a license, giving injections and megavitamin IV drips, hanging the bottles on clothes hooks, treating as many as 20 people a day from all over the country. He didn’t merely give injections; he would hold people’s hands and pray with them. He put all his patients on a strict diet of foods such as whole grains, fresh vegetables, fish, fertile eggs and chicken breasts. He urged patients to avoid aluminum pots, red meat, canned goods, alcohol, coffee, white flour and salt.”

According to the Times, the easiest part of Keller’s defense was disproving the government’s contention that the L-arginine serum used by Keller was “ineffective as a cancer treatment.” To refute that assertion, one of Keller’s five attorneys put several health researchers on the stand. They testified that computer searches of the standard medical databases showed some 20 to 25 articles, several of which were done at the National Cancer Institute itself, demonstrating that L-arginine either prevented cancerous tumors in the first place or, in the case of existing tumors, made them significantly shrink or disappear entirely. The papers ranged from a 1943 study showing that in 83% of the animals tested, rat tumors disappeared within two to three weeks when injected with L-arginine, to a 1991 Lancet study showing that when human volunteers were injected with large doses of L-arginine over a three-day period, their “natural-killer-cell activity rose a mean of 91%.”

Dr. Prendergast discusses what we can do with what we know right now about L-arginine:



In 2011 in the journal, Clinical Cancer Research, scientists at the University of Colorado Cancer Center showed that treatment with the over-the-counter amino acid arginine reactivates cancer-fighting T-cells in patients with glioblastoma, thus potentially allowing the immune system to help cleanse the body of cancer.

Most believe that every one of us has some cancer cells in our body all the time but our immune system is usually successful in destroying them. It just makes sense to have a strong immune system when fighting cancer, whether the FDA or CDC or the American Medical Association say so or not. We notice cancer when the cells overwhelm our immune system and grow into a noticeable tumor, so anything that strengthens the immune system is going to help us.

Nitric oxide (NO) can also have a multitude of effects on other aspects of tumor biology, including angiogenesis and metastasis. The American Society for Nutritional Sciences said in 1994 that arginine is a dibasic, cationic, semi-essential amino acid with numerous roles in cellular metabolism. It serves as an intermediate in the urea cycle and as a precursor for protein, polyamine, creatine and nitric oxide biosynthesis. Arginine stimulates the release of growth hormone, insulin-like growth factor 1, insulin, and prolactin. Furthermore, arginine influences pro-inflammatory cytokine levels. The discovery that L-arginine is the sole precursor for the multifunctional messenger molecule, nitric oxide, led to investigation into the role of arginine in numerous physiologic and pathophysiologic phenomena including cancer. In the past decade, the use of NO in the treatment of cancer has become a new field that has rapidly gained credibility and understanding.

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http://drsircus.com/cancer/larginine-cancer/
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Old 11-12-2017, 10:36 AM   #766
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Cannabis Cures Cancer


There should be no more confusion about whether or not marijuana is effective for cancer patients. Medical marijuana is chemotherapy, natural style, for all cancer patients. The two forms of hemp oil, one with THC and CBD and the other CBD alone (which is pretty much legal everywhere) provide the body with chemo therapeutics without the danger and staggering side effects. There are many essays in this site about cancer patients using marijuana and other itens from my protocol, but in this one we present a quick overview of the science that backs up the assertion that every cancer patient and every oncologist should put medical marijuana on their treatment maps.

What you will see in this essay is reference to many scientific studies that are all viewable on governmental sites. The United States government is pathetic in its dishonesty about medical marijuana both believing in it and holding patents for its medical use and claiming at the same time that it has no medical use. The federal government and still many states would rather throw innocent people in jail for using medical marijuana than be honest about how much it can help people recover from cancer and other diseases.

Below are summaries to just some of the scientific research out there that sustains the belief that medical marijuana will help people cure their cancer.
CBD and Breast Cancer

One of the most exciting areas of current research in the cannabinoid field is the study of the potential application of these compounds as antitumor drugs. CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness.[1],[2] The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive phenotype of breast cancer cells. Of the five cannabinoids tested: cannabidiol, cannabigerol, cannnabichromene; cannabidiol-acid and THC-acid, it was found that cannabidiol is the most potent inhibitor of cancer cell growth. Taken together, these data might set the bases for a cannabinoid therapy for the management of breast cancer.[3]
CBD and Lung Cancer
Results show that ?9-tetrahydrocannabinol reduces tumor growth, tumor number, and the amount/severity of lung metastases in MMTV-neu mice.[4] Cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequentdecreased cancer cell invasiveness thus inhibits lung cancer invasion and metastasis.[5]
Learn a system of medicine that is safe, simple and affordable! Discover Dr Sircus Natural Allopathic Medicine »

Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. Researchers have observed expression of CB1 (24%) and CB2 (55%) in NSCLC patients. They have also shown that the treatment of NSCLC cell lines (A549 and SW-1573) with CB1/CB2- and CB2-specific agonists Win55,212-2 and JWH-015, respectively, significantly attenuated random as well as growth factor-directed in vitro chemotaxis and chemoinvasion in these cells.[6]

Researchers in lung cancers also reported that they observed significant reduction in focal adhesion complex, which plays an important role in cancer migration. Medical marijuana significantly inhibited in vivo tumor growth and lung metastasis (?50%).[7]
CBD and Pancreatic Cancer

In research on pancreatic cancer it was found that cannabinoids lead to apoptosis of pancreatic tumor cells via a CB2 receptor and de novo synthesized ceramide-dependent up-regulation of p8 and the endoplasmic reticulum stress–related genes ATF-4 and TRB3. These findings may contribute to set the basis for a new therapeutic approach for the treatment of pancreatic cancer as reported by the National Cancer Institute.
CBD and Prostate Cancer

Prostate cancer cells possess increased expression of both cannabinoid 1 and 2 receptors, and stimulation of these results in decrease in cell viability, increased apoptosis, and decreased androgen receptor expression and prostate-specific antigen excretion.[8]
CBD and Colorectal Carcicoma

In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPAR?-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms.[9]

Ovarian cancer represents one of the leading cause of cancer-related deaths for women and is the most common gynecologic malignancy. Results with medical marijuana support a new therapeutic approach for the treatment of ovarian cancer. It is also conceivable that with available cannabinoids as lead compounds, non-habit forming agents that have higher biological effects could be developed.[10]
CBD and leukaemia and lymphoma cell

Examination of a number of human leukaemia and lymphoma cell lines demonstrate that CB2 cannabinoid receptors expressed on malignancies of the immune system may serve as potential targets for the induction of apoptosis. Also, because CB2 agonists lack psychotropic effects, they may serve as novel anticancer agents to selectively target and kill tumors of immune origin.[11] Plant-derived cannabinoids, including Delta9-tetrahydrocannabinol (THC), induce apoptosis in leukemic cells.[12]

Cannabinoid-treated tumors showed an increased number of apoptotic cells. This was accompanied by impairment of tumor vascularization, as determined by altered blood vessel morphology and decreased expression of proangiogenic factors (VEGF, placental growth factor, and angiopoietin. Abrogation of EGF-R function was also observed in cannabinoid-treated tumors.[13] These results support a new therapeutic approach for the treatment of skin tumors.
CBD and Hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the third cause of cancer-related death worldwide. When these tumors are in advanced stages, few therapeutic options are available. In this study, the effects of cannabinoids–a novel family of potential anticancer agents–on the growth of HCC was investigated. It was found that ?(9)-tetrahydrocannabinol (?(9)-THC, the main active component of Cannabis sativa) and JWH-015 (a cannabinoid receptor 2 (CB(2)) cannabinoid receptor-selective agonist) reduced the viability of the human HCC cell lines Cannabinoids were able to inhibit tumor growth and ascites in an orthotopic model of HCC xenograft.[14] These findings may contribute to the design of new therapeutic strategies for the management of HCC.

Both cholangiocarcinoma cell lines and surgical specimens from cholangiocarcinoma patients expressed cannabinoid receptors. THC inhibited cell proliferation, migration and invasion, and induced cell apoptosis. THC also decreased actin polymerization and reduced tumor cell survival in anoikis assay. pMEK1/2 and pAkt demonstrated the lower extent than untreated cells. Consequently, THC is potentially used to retard cholangiocarcinoma cell growth and metastasis.[15]

Smoking marijuana might decrease the smoker’s risk for bladder cancer, a new study shows. Retrospectively analyzing a large database of patients, researchers at Kaiser Permanente in California found that patients who reported cannabis use were 45% less likely to be diagnosed with bladder cancer than patients who did not smoke at all.

THC is a potent inducer of apoptosis, even at 1 x IC(50) (inhibitory concentration 50%) concentrations and as early as 6 hours after exposure to the drug. These effects were seen in leukemic cell lines (CEM, HEL-92, and HL60) as well as in peripheral blood mononuclear cells.[16] Cannabinoids represent a novel class of drugs active in increasing the life span in mice carrying Lewis lung tumors and decreasing primary tumor size.[17]

CBD and Cervical Cancer

Research has also found a cannabidiol-driven impaired invasion of human cervical cancer (HeLa, C33A) and human lung cancer cells (A549) that was reversed by antagonists to both CB(1) and CB(2) receptorrs as well as to transient receptor potential vanilloid 1 (TRPV1). The decrease of invasion by cannabidiol appeared concomitantly with up regulation of tissue inhibitor of matrix metalloproteinases-1 (TIMP the findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers.[18]

A new anticancer quinone (HU-331) was synthesized from cannabidiol. It shows significant high efficacy against human cancer cell lines in vitro and against in vivo tumor grafts in nude mice. Two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabidiol-dimethylheptyl (CBD-DMH), induced apoptosis in a human acute myeloid leukemia (AML) HL-60 cell line.[19]

Other studies show a synthetic and potent cannabinoid receptor agonist, investigated in hepatoma HepG2 cells and a possible signal transduction pathway that is proposed, indicates a potential positive role in liver cancer.[20]Cannabinoids have been found to counteract intestinal inflammation and colon cancer.[21]

The control of the cellular proliferation has become a focus of major attention as opening new therapeutic possibilities for the use of cannabinoids as potential antitumor agents.[22] Cannabinoid treatment inhibits angiogenesis of gliomas in vivo.[23] Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas. Other confirming studies may provide the basis for a new therapeutic approach for thetreatment of malignant gliomas.[24]
Cannabinoid in Cancer Treatment – Summary

Cannabinoids are found to exert their anti-cancer effects in a number of ways and in a variety of tissues.

Triggering cell death, through a mechanism called apoptosis
Stopping cells from dividing
Preventing new blood vessels from growing into tumours
Reducing the chances of cancer cells spreading through the body, by stopping cells from moving or invading neighbouring tissue
Speeding up the cell’s internal ‘waste disposal machine’ – a process known as autophagy – which can lead to cell death

All these effects are thought to be caused by cannabinoids locking onto the CB1 and CB2 cannabinoid receptors. Almost daily we are seeing new or confirming evidence that Cannibinoids can be used to great benefit in cancer treatment of many types.

Buy the new Medical Marijuana 2nd Edition eBook!

http://drsircus.com/medical-marijuan...-cures-cancer/

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The only human data we have was published back in 2006. It was a trial in which nine patients all with recurrent glioblastoma multiforme (rGBM) were recruited https://www.nature.com/articles/6603236 After maximal safe surgical resection a Rickham reservoir was placed into the cavity that had been left. Then every day doctors would inject a very pure (delta-9)THC solution at a high concentration into where the tumour had been, in the hope that it would have antiangiogenic effects, reduce invasion, cell survival, etc and this would help kill off any remaining cancer cells. The median survival (mOS) of the group was just 6 months which is what is generally expected with patients who have rGBM http://n.neurology.org/content/73/15/1200.long https://jamanetwork.com/journals/jam...stract/1764056 As for the two patients who survived the longest (yet still died), the effects could be attributable to spontaneous but temporary regression of the disease https://jamanetwork.com/journals/jam...article/265874 which happens, amount of surgical resection https://academic.oup.com/neuro-oncol.../4/462/2509369 or a number of other factors like the drugs they were prescribed http://casereports.bmj.com/content/2...16-217393.long

I guess they got the funding for that based on preclinical studies such as this https://www.nature.com/articles/nm0300_313 In it rats had implanted brain gliomas and were treated with intratumoral (delta-9)THC. They had improved survival compared to the control and it cured three of the fifteen (20%).
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 12-12-2017, 03:58 PM   #767
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CD47, is over-expressed in many types of cancers. Its expression on the surface of cancer cells is used as a mechanism to protect itself from phagocytosis (a process of ingestion) by macrophages, a type of white blood cell that engulfs and digests damaged and abnormal cells, as well as foreign substances and pathogens. Specifically, CD47 when expressed at the cell surface binds to the signal regulatory protein-a (SIRP-a), a protein expressed by macrophages, triggering a signaling cascade that culminates with the inhibition of the phagocytic process.


Human macrophages are in red and human acute myeloid leukaemia (AML) cancer cells are in green. These cells have high amounts of CD47 and aren't killed by macrophages


The same pic, but with an SIRP-a antibody used




4 companies and 2 charities so far (the more the better). Three Phase I trials should have started by the end of this year http://trilliumtherapeutics.com/file...es-Q2-2015.pdf
Two updates from Trillium Therapeutics who are conducting trials.

The first poster presentation http://s2.q4cdn.com/772010778/files/...4116-FINAL.pdf for TTI-621 was a summary from the study (NCT02663518) evaluating intravenous TTI-621 in patients with relapsed/refractory hematologic malignancies and those with diffuse large B-cell lymphoma (DLBCL). Weekly infusions continue to be well tolerated and they plan to increase the dosage in select patients. When administered in combination with Rituximab, objective responses occurred in 27% (5/18) DLBCL patients along with others demonstrating extended progression-free periods. Keep in mind these were patients that had already been heavily pretreated.

Here is a PET scan of one patient with a CR


Their second poster http://s2.q4cdn.com/772010778/files/...4076-FINAL.pdf was data from the ongoing intratumoral trial (NCT02890368). Injections resulted in rapid reduction in CAILS scores (measures of local lesion(s) responses) in 90% (9/10) of mycosis fungoides patients. Additionally, in 3 of 3 patients a reduction in circulating leukemic Sézary cells was observed. Importantly, the injection was well tolerated with no dose-limiting toxicities. In sum, the data was encouraging and as a result patients continue to be enrolled.

Here is data from two patients


The CEO Dr. Stiernholm stated the following: ''The regression of local tumor lesions observed in most CTCL patients treated with intratumoral TTI-621 monotherapy provides us with a rationale to initiate a sharply focused effort to characterize efficacy in this largely incurable disease, as well as other forms of T-cell lymphoma. Having completed the dose-escalation phase, we are now pursuing weekly dosing in the intratumoral trial with the goal of inducing systemic responses. In parallel, we continue to enroll a wide variety of T-cell lymphoma patients, including CTCL, into an expanded cohort in the intravenous TTI-621 trial. Notwithstanding the added level of complexity associated with developing combination therapies, the emerging signal in the DLBCL cohort is intriguing, especially since these patients have previously progressed after rituximab therapy. With growing evidence supporting the tolerability of dose intensification we are now able to assess whether increasing systemic exposure of TTI-621 leads to greater anti-tumor activity in patients, including those with T-cell malignancies.''
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Old 16-12-2017, 07:48 AM   #768
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Magnesium is Basic to Cancer Treatment

I recommend high intake of magnesium for many reasons, and it has appeared as the lead or most important component of my Natural Allopathic protocol until the appearance of molecular hydrogen, which now competes with it, in terms of importance and priority. In reality, they work together and amplify each other for immediate and often great medical effect.

Hospitals in China and Japan have recently discovered hydrogen and are already using it in their hospitals. Magnesium however, continues to be underutilized in medicine, even though it is the ultimate cardio medicine, crucial for diabetics and suffers of metabolic syndrome and essential for patients with cancer.

Magnesium is basic to cancer treatment and its avoidance. Several studies have shown an increased cancer rate in regions with low magnesium levels in soil and drinking water. In Egypt, the cancer rate was only about 10% of that in Europe and America. In the rural fellah, it was practically nonexistent. The main difference was an extremely high magnesium intake of 2.5-3 g in these cancer-free populations, ten times more than in most western countries.[1]

An inverse relationship between cancer prevalence and the magnesium content of water and of soil is reported in studies, starting more than 50 years ago. A Russian report showed that stomach cancer is four times more common in the Ukraine where the magnesium content of soil and drinking water is low, than it is in Armenia where the magnesium content is more than twice as high. A more recent morphologic and statistical analysis of neoplastic deaths in two Polish communities disclosed a nearly three-fold higher death rate in the community with Mg-poor soil than in the one with Mg-rich soil (10%).

Flooding the body with magnesium increases a person’s chance of surviving cancer and living a longer pain free life. When I say flood it behooves a cancer patient to simultaneously use different forms of magnesium and different forms of administration.

One can take magnesium orally; nebulize it into the lungs, and use transdermally through either direct application to the skin or in baths. Moreover, in emergency rooms and intensive care wards they give magnesium intravenously and by subcutaneous injection for cardiac arrest when all their pharmaceutical drugs fail.

One would use magnesium chloride in its purest form for many of these applications but there is also magnesium bicarbonate that is perfect to add to one’s water. Drinking high concentrated molecular hydrogen water part of the day and magnesium bicarbonate at other times would greatly boost cellular recovery, extend life, boost sports performance, reduce pain and do a host of heavy lifting in medical terms.

For oral use of magnesium to be used with hydrogen, I am recommending MYO-MAG as an advanced, formula that contains ingredients known to participate in the production of ATP in the body. It provides magnesium in the form of malate and diglycinate, as well as Vitamins B1, B2, and B6 (including coenzyme forms of these vitamins). One capsule contains 100 mg of magnesium and 300 mg of malic acid. In practice, I have used magnesium oil orally, which does wonders to move the intestines if one is constipated.

Magnesium baths using bath flakes, Epson salts or Dead Sea Salt (have received occasional reports about toxicity of materials coming from the Dead Sea) would greatly augment ones recovery and help usher cancer remissions, especially when used in conjunction with hyperthermia and other essential treatment components like sodium bicarbonate, iodine, selenium, oxygen, carbon dioxide, medical marijuana and super foods.

Researchers from Japan’s National Cancer Center in Tokyo have found that an increased intake of magnesium reduces a man’s risk of colon cancer by over 50 percent. Men with the highest average intakes of magnesium (at least 327 mg/d) were associated with a 52 percent lower risk of colon cancer, compared to men who consumed the lowest average intakes. Published in the Journal of Nutrition,[2] the research studied 87,117 people with an average age of 57 and followed them for about eight years. Dietary intakes were assessed using a food frequency questionnaire. Average intakes of magnesium for men and women were 284 and 279 milligrams per day.

My suggestion, especially for late stage cancer patients would be constant oral intake with magnesium in conjunction with daily magnesium massages and daily baths to pump in as much magnesium as possible. One does not have to worry about taking too much magnesium unless the kidneys, which functions to eliminate excess magnesium, are failing. When used with the hydrogen and instant acting bicarbonate one should expect to move some medical mountains.
Diabetics Will See Results

Many doctors today understand the relationship between cancer and diabetes so it should come as no surprise that the above suggestions would work for diabetic patients. In fact, a meta-analysis of prospective cohort studies by researchers at Stockholm’s Karolinska Institutet reported that for every 100-milligram increase in magnesium intake, the risk of developing type 2 diabetes decreased by 15 percent. One of the reason insulin is so important is that without insulin magnesium is not transported from our blood into our cells where it is most needed. It is a deadly loop. Low serum and intracellular magnesium concentrations are associated with insulin resistance, impaired glucose tolerance, and decreased insulin secretion.

In the U.S., combined annual costs for treating diabetes along with additional factors such as lost productivity amount to $174 billion, according to the American Heart Association. Heart experts worry that without better ways to prevent and treat diabetes, the disease threatens to reverse nearly a half-century of advances against cardiovascular disease, which remains the world’s leading killer. We can add hundreds of billions of dollars more to cover the costs of cancer.

Many years ago, I wrote Magnesium – The Ultimate Heart Medicine. We already have these better ways to prevent and treat diabetes but because doctors practice with blinders on we find that the majority of cardiologists and the American Heart Association have still not discovered what has been in plain sight for decades.
Magnesium is Fundamental

Magnesium stabilizes ATP,[4] allowing
DNA and RNA transcriptions and repairs.[5]

There is no substitute for magnesium in human physiology; nothing comes even close to it in terms of its effect on overall cell physiology. Without sufficient magnesium, the body accumulates toxins and acid residues, degenerates rapidly, and ages prematurely. It goes against a gale wind of medical science to ignore magnesium in the treatment of any chronic or acute disorder, especially cancer.

Magnesium repletion produced rapid
disappearance of periosteal tumors.[6]

Aleksandrowicz et al. in Poland conclude that inadequacy of magnesium and antioxidants are important risk factors in predisposing to leukemias.[7] Other researchers found that 46 percent of the patients admitted to an ICU in a tertiary cancer center presented hypomagnesemia. They concluded that the incidence of hypomagnesemia in critically ill cancer patients is high.[8] The primer antioxidant just happens to be molecular hydrogen, which can be administered in different ways.

Over 300 different enzymes systems rely upon magnesium
to facilitate their catalytic action, including ATP
metabolism, creatine-kinase activation, adenylate-cyclase,
and sodium-potassium-ATPase.[9]

Dr. Andrzej Mazur has shown in experimentally induced magnesium deficiency in rats that after only a few days a clinical inflammatory syndrome develops and is characterized by leukocyte (white blood cell) and macrophage activation, release of inflammatory cytokines and excessive production of free radicals. “Magnesium deficiency induces a systemic stress response by activation of neuro endocrinological pathways. Magnesium deficiency contributes to an exaggerated response to immune stress and oxidative stress is the consequence of the inflammatory response,” writes Dr. Mazur. This gives us more than enough reason to always combine hydrogen with magnesium.

It is known that carcinogenesis induces magnesium distribution disturbances, causing magnesium mobilization through blood cells and magnesium depletion in non-neoplastic tissues. Magnesium deficiency seems to be carcinogenic, and in the case of solid tumors, a high level of supplemented magnesium inhibits carcinogenesis.[10] Both carcinogenesis and magnesium deficiency increase the plasma membrane permeability and fluidity. Scientists have in fact found out that there is much less Mg++ binding to membrane phospholipids of cancer cells than to normal cell membranes.[11]

It has been suggested that magnesium deficiency may trigger carcinogenesis by increasing membrane permeability.[12] The membranes of magnesium-deficient cells seem to have a smoother surface and decreased membrane viscosity than normal cells, analogous to changes in human leukemia cells.[13],[14] And we find that lead (Pb) salts are more leukemogenic when given to magnesium-deficient rats than when they are given to magnesium-adequate rats, suggesting that magnesium is protective.[15]

Magnesium has an effect on a variety of cell membranes
through a process involving calcium channels and ion transport
mechanisms. Magnesium is responsible for the maintenance
of the trans-membrane gradients of sodium and potassium.
Conclusion

The latest information about cancer and its cause is that it is mostly environmental and external factors like smoking, drinking, diet, getting too much sun and exposure to toxic chemicals that cause cancer, rather than intrinsic factors like random cell mutations.

Magnesium deficiencies are hidden behind the word diet, which in todays civilized world is severely lacking in the mineral. All white foods are cancerous because the magnesium has been stripped out making them white. Even healthy foods do not have the nutritional content they used to so it is almost impossible to get enough magnesium even when eating right.

The involvement of free radicals in tissue injury induced by Mg deficiency causes an accumulation of oxidative products in heart, liver, kidney, skeletal muscle tissues and in red blood cells. Free radicals are the friction of life. Magnesium deficiency has been associated with production of reactive oxygen species, cytokines, and eicosanoids, as well as vascular compromise in vivo. Although magnesium deficiency induced, inflammatory change occurs during "chronic" magnesium deficiency in vivo, acute magnesium deficiency may also affect the vasculature and consequently, predispose endothelial cells (EC) to perturbations associated with chronic oxidative stress.[16]

http://drsircus.com/magnesium/magnes...cer-treatment/
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Old 20-12-2017, 06:34 AM   #769
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Soft tissue sarcoma (STS) is a group (50+) of rare malignancies with variable presentation, behaviour and outcome http://journals.lww.com/annalsofsurg...atients.2.aspx The prognosis of advanced or metastatic STS is limited https://www.karger.com/Article/FullText/362631 with overall survival in the second-line and beyond setting around 11.7-13.5 months http://www.thelancet.com/journals/la...651-5/fulltext http://www.thelancet.com/journals/la...283-0/fulltext http://ascopubs.org/doi/full/10.1200/JCO.2015.62.4734 https://bmcmedicine.biomedcentral.co...916-017-0831-7

The cancer testes antigen NY-ESO-1 is frequently expressed in certain STS https://www.nature.com/articles/modpathol2014155 and high expression may be associated with poor prognosis http://onlinelibrary.wiley.com/doi/10.1002/cjp2.16/full http://www.humanpathol.com/article/S...344-6/fulltext So effectively targeting NY-ESO-1 with new immunotherapies in the right patient population could lead to prolonged benefit for them.

LV305 acts as a primer. It is a lentiviral vector which encodes a full length NY-ESO-1 RNA. This targets certain immune (dendritic) cells in the patient. The vaccine induces and/or expands anti-NY-ESO-1 CD4+ and CD8+ T-cells. G305 acts as a booster. This contains a potent TLR-4 agonist (this is implicated in the recognition of various bacterial cell wall components) and is co-formulated with an NY-ESO-1 full length protein. It enhances the LV305 induced T-cell immunogenicity and triggers anti-NY-ESO-1 antibodies. A Phase Ib trial combining both (CMB305) is now recruiting https://clinicaltrials.gov/ct2/show/NCT02387125

Single agent activity of LV305 has been shown in a Phase Ia trial. The one year overall survival rate was 81% and the median (half) OS rate has not been reached. It was safe and well tolerated with Grade 1 (mild) and 2 (moderate) adverse events that were mostly ''flu like'' in nature.

The video below comes from this article https://www.ivanhoe.com/medical-brea...immune-system/


Early data from the combo study shows the 12 month OS rate was 83.1% and 18 month OS rate was 76.2%. The median OS hasn't been reached and the AEs have been similar to single agent LV305. A trial for the TLR-4 agonist injected directly into a tumour along with radiotherapy is also recruiting https://clinicaltrials.gov/ct2/show/NCT02180698 Some data from an early one has been shared http://www.oncotherapynetwork.com/bo...croenvironment
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 20-12-2017, 12:31 PM   #770
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If you are saying big pharma has no cure for cancer, dc, then I agree wholeheartedly on that fact. Cancer is not an incurable disease, it is a multi-billion dollar industry.
Many are curable (long-term durable remissions). The survival rates are improving too http://www.cancerresearchuk.org/heal...stics/survival https://sciencebasedmedicine.org/con...war-on-cancer/

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L-Arginine & Cancer

On December 15, 1991 the LA Times published a large expose about Jimmy Keller, a man dedicated to healing and experimental medicine. The government believed he was a con man, kidnapped him in Mexico, convicted him of fraud and put him in jail. Interestingly and importantly, the 1999 Nobel Prize research showed him to have been a medical genius. Almost all our understanding of arginine, a simple amino acid, comes in the years following Keller’s conviction.

Researchers around the world are serious about the use of amino acids in cancer treatment. L-arginine is the common substrate for two enzymes, arginase and nitric oxide synthase (NOS). As a precursor to nitric oxide, it is a key component of endothelial-derived relaxing factor. The endothelium is the lining inside blood vessels and arginine supplements help make more nitric oxide, which helps to relax and dilate blood vessels. The body needs higher levels of arginine when it is under conditions of stress, illness, malnutrition or injury. When these conditions are present, arginine becomes essential for healing to occur.

Dr. Joe Prendergast, a longtime expert on the power of L-arginine says, “Arginine uses the two natural pathways into the brain to promote anti-aging properties, sports performance, and boost the immune system. Because L-arginine promotes healthy blood flow, it can also benefit human sexuality.” Arginine overcomes cardiovascular issues and reverses atherosclerosis[1]. Dr. Prendergast is proud to say that all his patients through the last 17 years have managed to not succumb to any strokes, heart attacks or even to diabetes.

Arginine is used to treat conditions that improve with increased blood flow, such as chest pains, erectile dysfunction, clogged arteries, vascular disease and headaches, according to the Mayo Clinic.
Arginine is one of the 20 most common natural amino acids and this is what Keller was injecting intelligently into his cancer patients’ veins. When he administered the amino acid solution intravenously into himself first, he was astonished. “I felt a tingling in my tumor areas. They got softer. It was phenomenal.”

The LA Times article explains how, when Keller gave a patient an injection of Tumorex[2], the patient would start feeling heat in their tumor (a thermometer placed on the tumor, Keller said, showed a temperature rise of one to two degrees). There was a pulling, tingling, grabbing sensation. One patient said it felt like a thousand little fingers pulling at her tumors. People with brain tumors heard popping and cracking sounds as if fireworks were going off in their heads. Tumorex didn’t always work with everyone, but when it did, Keller said, the results could be spectacular. Within hours, patients reported, tumors began to soften and shrink, and within days they began to disappear. “On open tumors,” Keller said, “you could actually see bubbles.”

The LA Times explains further how visitors to the Keller clinic would be astounded. They’d tell stories about having seen people who would come to the clinic near death, and who, after a few days or few weeks of treatment, would be back on their feet again, walking, shopping and ready to resume their normal lives. Dr. George Eisberg, an Albuquerque family physician who testified at Keller’s trial, told of escorting a dying friend to Keller’s clinic. “I wheeled him in in a wheelchair. He couldn’t swallow.” But as soon as Keller put him on the IV drip, the patient’s chest pain subsided so much that for dinner that night he went out and ordered a lobster and a pina colada.

The Times said that, “Keller openly practiced medicine without a license, giving injections and megavitamin IV drips, hanging the bottles on clothes hooks, treating as many as 20 people a day from all over the country. He didn’t merely give injections; he would hold people’s hands and pray with them. He put all his patients on a strict diet of foods such as whole grains, fresh vegetables, fish, fertile eggs and chicken breasts. He urged patients to avoid aluminum pots, red meat, canned goods, alcohol, coffee, white flour and salt.”

According to the Times, the easiest part of Keller’s defense was disproving the government’s contention that the L-arginine serum used by Keller was “ineffective as a cancer treatment.” To refute that assertion, one of Keller’s five attorneys put several health researchers on the stand. They testified that computer searches of the standard medical databases showed some 20 to 25 articles, several of which were done at the National Cancer Institute itself, demonstrating that L-arginine either prevented cancerous tumors in the first place or, in the case of existing tumors, made them significantly shrink or disappear entirely. The papers ranged from a 1943 study showing that in 83% of the animals tested, rat tumors disappeared within two to three weeks when injected with L-arginine, to a 1991 Lancet study showing that when human volunteers were injected with large doses of L-arginine over a three-day period, their “natural-killer-cell activity rose a mean of 91%.”

Dr. Prendergast discusses what we can do with what we know right now about L-arginine:



In 2011 in the journal, Clinical Cancer Research, scientists at the University of Colorado Cancer Center showed that treatment with the over-the-counter amino acid arginine reactivates cancer-fighting T-cells in patients with glioblastoma, thus potentially allowing the immune system to help cleanse the body of cancer.

Most believe that every one of us has some cancer cells in our body all the time but our immune system is usually successful in destroying them. It just makes sense to have a strong immune system when fighting cancer, whether the FDA or CDC or the American Medical Association say so or not. We notice cancer when the cells overwhelm our immune system and grow into a noticeable tumor, so anything that strengthens the immune system is going to help us.

Nitric oxide (NO) can also have a multitude of effects on other aspects of tumor biology, including angiogenesis and metastasis. The American Society for Nutritional Sciences said in 1994 that arginine is a dibasic, cationic, semi-essential amino acid with numerous roles in cellular metabolism. It serves as an intermediate in the urea cycle and as a precursor for protein, polyamine, creatine and nitric oxide biosynthesis. Arginine stimulates the release of growth hormone, insulin-like growth factor 1, insulin, and prolactin. Furthermore, arginine influences pro-inflammatory cytokine levels. The discovery that L-arginine is the sole precursor for the multifunctional messenger molecule, nitric oxide, led to investigation into the role of arginine in numerous physiologic and pathophysiologic phenomena including cancer. In the past decade, the use of NO in the treatment of cancer has become a new field that has rapidly gained credibility and understanding.

Read more:
http://drsircus.com/cancer/larginine-cancer/
Oral supplementation has been investigated as a potential therapy https://www.spandidos-publications.com/ijo/12/1/221 http://onlinelibrary.wiley.com/doi/1...97.02528.x/pdf However, major limitations to this include severe GI distress and extensive metabolism by the intestinal mucosa http://jn.nutrition.org/content/128/8/1249.long http://jn.nutrition.org/content/137/6/1693S.long http://onlinelibrary.wiley.com/doi/1...9.00278.x/full This is why drugs like CB-1158 https://www.calithera.com/publications/ are needed. As for Tumorex then you can read more about that here https://www.quackwatch.org/01Quacker...r/tumorex.html
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 24-12-2017, 10:48 PM   #771
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Thank you for your message to masses. I do not think cancer is a bad word. People are getting upset because of it, though this is something that people face when they meet this issue in their lives. I am with you
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Old 27-12-2017, 02:22 PM   #772
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The thing about cancer. Well let’s put it in personal terms. I wouldn’t give an ounce of bulshit if I ended up getting cancer. For all I know I have it already. The real problem with cancer is when some body else gets it. That is the point at which you are in big shit. The way cancer gets to you is not by attacking you, but by attacking those whom have no business getting it in the first place.

There are those of course who should get cancer and should be made to get cancer. But equaly there are those who should not get cancer. We live in a world where this law is not adhered to. Therefore there is something wrong with the world. The world is run by aliens. Aliens who themselves are the cancer.

By studying the nature of cancer it is possible to see reptillians as cancer. A reptillian pretends to be something that it isn’t. It is a malignancy that is destroying the earth. An infection that came from elsewhere. Cancer disguises itself as “good”. Cancer Research is disguised as good. But these charities are cancer disguised as something good.

You see these letters come through the post saying, “give to Cancer Research”. Note, they want your money but not your ideas. They don’t want you to come in here and find a cure for cancer. They just want your money, so they can pay for whores and private jets and bomb the world to make it as uninhabitable as possible so that their cancer can spread and transform this planet into one that is as dead as Mars and the other lifeless corpses of this solar system taken for planets.

The cure for cancer is for people to realise that what is cancer and what is not, and then give the cancer to all that which is cancer, and have the cancer itself become obliterated. This means that to end cancer, physical action must be taken within this matrix that is a fake reality.
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Old 13-01-2018, 08:47 AM   #773
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Dr.Sircus - Your Channel for Health and News

https://www.youtube.com/user/IMVAPublications


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Old 18-01-2018, 10:52 AM   #774
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Dr.Sircus - Your Channel for Health and News

https://www.youtube.com/user/IMVAPublications

Tullio Simoncini has finally been sentenced to 5 years and 6 months for manslaughter and improper exercise of the medical profession after one patient he ''treated'' died https://www.wired.it/scienza/medicin...cro-simoncini/ Many others have too http://www.123hjemmeside.dk/cancer_i...ungus/21160738

I know ''Dr'' Sircus has recommend bicarb as a treatment for cancer in the past.
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?
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Old 18-01-2018, 11:04 AM   #775
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Tullio Simoncini has finally been sentenced to 5 years and 6 months for manslaughter and improper exercise of the medical profession after one patient he ''treated'' died https://www.wired.it/scienza/medicin...cro-simoncini/ Many others have too http://www.123hjemmeside.dk/cancer_i...ungus/21160738

I know ''Dr'' Sircus has recommend bicarb as a treatment for cancer in the past.

Aliases who copy and paste the exact same information as dumbcritic try to sell fake CBD oil on the web. They even tried it here on the forum.
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Old 19-01-2018, 01:11 AM   #776
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Old 19-01-2018, 08:01 AM   #777
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Many are curable (long-term durable remissions). The survival rates are improving too http://www.cancerresearchuk.org/heal...stics/survival https://sciencebasedmedicine.org/con...war-on-cancer/



Oral supplementation has been investigated as a potential therapy https://www.spandidos-publications.com/ijo/12/1/221 http://onlinelibrary.wiley.com/doi/1...97.02528.x/pdf However, major limitations to this include severe GI distress and extensive metabolism by the intestinal mucosa http://jn.nutrition.org/content/128/8/1249.long http://jn.nutrition.org/content/137/6/1693S.long http://onlinelibrary.wiley.com/doi/1...9.00278.x/full This is why drugs like CB-1158 https://www.calithera.com/publications/ are needed. As for Tumorex then you can read more about that here https://www.quackwatch.org/01Quacker...r/tumorex.html


Your "oral supplementation" test included the use of chemotherapy, which annuls any test as chemo can cause death.
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Old 03-02-2018, 09:24 PM   #778
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https://forum.davidicke.com/showpost...&postcount=767 The trial https://clinicaltrials.gov/ct2/show/NCT02890368 testing IT injections of TTI-621 has been updated. New cohorts have been added to test it with PD-1/PD-L1 inhibitors, pegylated interferon-a2a (for those with CTCL), Imlygic/T-Vec or radiation. The target enrollment has changed from 54 to 240 patients as well.

https://forum.davidicke.com/showpost...&postcount=769 The company has given an update on G100. The poster http://www.immunedesign.com/wp-conte...v1-25Jan18.pdf includes updated (with a mean 156 days of follow up) data on 15 patients (this was originally presented at AACR last year http://cancerres.aacrjournals.org/co...upplement/2947). There have been improved responses over time. The local tumour control rate was 100% (14/14 evaluable tumours). The abstract also showed that G100 with or without radiation increased tumour-specific CD4+ T-cells, including an increase in clonality of PBMCs in 8 of 14 patients with tumour infiltrating lymphocytes increasing in all of them (a good thing). Seven of the 13 had increased polyfunctionality in those CD4+ T-cells (another good thing) and there is additional data on the responses in some individual patients. The authors concluded that G100 may sensitise tumours to radiation. Clonal overlap of CD4+ and CD8+ T-cells in pretreatment tumour infiltrating lymphocytes could serve as a potential predictor of response to it.
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 03-02-2018, 09:32 PM   #779
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Your "oral supplementation" test included the use of chemotherapy, which annuls any test as chemo can cause death.
Everything in life has benefits and risks. The treatments for cancer are no different. These are discussed with the patient and they then must chose whether or not to have any treatment(s). If we take the use of adjuvant (after surgery) chemo, targeted and hormonal therapies then all of these have contributed to a decline in mortality from breast cancer by ~40% since 1989 in the US http://onlinelibrary.wiley.com/doi/1...aac.21412/full Data from the UK (in breast and lung cancer patients) shows that when chemo is given for curative (long-term durable remissions) intent the benefits outweigh the risks http://www.thelancet.com/journals/la...383-7/fulltext

So it would be unethical to withhold proven treatments from patients. That's not to say it hasn't happened in the past https://respectfulinsolence.com/2009...-than-useless/ https://respectfulinsolence.com/2009...to-the-failed/

In reality you'd hope the experimental drug would improve standard of care (sadly a larger PhIII was never conducted https://breast-cancer-research.biome...0.1186/bcr1505 https://www.futuremedicine.com/doi/a...217/imt.13.126) and over time change it https://www.businesswire.com/news/ho...vival-Compared Once the latter happens you start to build on this and add other therapies like Epacadostat https://meetinglibrary.asco.org/record/145486/abstract I know in the next few months a triplet testing that, Keytruda and INCB001158 https://www.calithera.com/arginase-i...or-incb001158/ will open for a range of cancers. Assuming it's well tolerated then you might test a fourth drug like CB-839 https://www.calithera.com/glutaminase-inhibitor-cb-839/ The hope would be to improve the depth and duration of responses.

Checkpoint inhibitors (CI's) like Keytruda are standard of care for many types of cancer but not all patients benefit. The absence of immune activation is common in patients who fail to respond http://stm.sciencemag.org/content/5/200/200ra116.long If we take NSCLC as an example then ~80% of patients have low levels of PD-L1 and for those drugs like that simply won't work. Thankfully companies like Dynavax have created inhaled treatments like DV281 http://files.shareholder.com/downloa...Poster2_NC.pdf to drive an immune response and this should then synergise with CI's. A PhIb trial is testing the combo is now ongoing https://clinicaltrials.gov/ct2/show/NCT03326752 Other preclinical studies shows this can be improved upon even further http://onlinelibrary.wiley.com/doi/1...ijc.28028/full http://www.tandfonline.com/doi/full/...X.2015.1040214 http://www.tandfonline.com/doi/full/...X.2016.1234571 https://www.sciencedirect.com/scienc...08874917300047
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

Last edited by dumbcritic; 04-02-2018 at 07:53 PM.
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Old 07-03-2018, 06:19 PM   #780
mannybash
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What a great thread to have! Will more a bit later. Suffice it to say that it's difficult to get it through people's heads about this. If the health shop us I dependant there is more chance of being able to advertise something. One nit far from here us run by vegetarians and they have sold copies if Dr. Clarks book and others so there probably would not be a problem.
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