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View Poll Results: Should we globally legalize hemp and/or marijuana?
Yes, hemp should be globally legalized! 24 39.34%
No, hemp should NOT be globally legalized! 4 6.56%
Hemp and marijuana should be globally legalized! 42 68.85%
I believe Christ should start a global online government! 4 6.56%
Multiple Choice Poll. Voters: 61. You may not vote on this poll

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Old 16-06-2015, 08:51 PM   #21
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The cover of the June edition of the National Geographic (Weed: The Science of Marijuana) says it all, seems to be a reasonably unbiased report, though have only skim read..
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Old 16-06-2015, 09:07 PM   #22
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We need to remember that there are 100 to over 200 different types of cancer (the actual number depends on how some researchers subdivide some types) in humans. Each of these different cancers have different genetics, different prognoses, different causes, and different treatments. In other words, it is not one singular disease with one unified course of treatment. Every cancer is so different with such different physiology, there is just never going to be a magic pill. However clinical trials are ongoing https://clinicaltrials.gov/ct2/show/...+cancer&rank=8 https://clinicaltrials.gov/ct2/show/...+cancer&rank=7 with more to start soon http://www.gwpharm.com/oncology.aspx
I dont get why you would wish to promote the same criminals who have kept this plant on lock down for so long tbh.
Sativex is a scam to rob the tax payer & yet another insult to the thousands of patients out there living in misery who need legalisation.

You might as well promote Marinol another scam by big pharma greed machine to keep people sick rather than just give them the real thing.

http://clear-uk.org/the-sativex-scam/
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Old 16-06-2015, 09:15 PM   #23
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I used cannabis oil when I first became a ti, I said that I thought I was a paranoid schizo, I actually posted about it on here from an account I no longer have access to.

Cannabis is not the wonder drug people want it to be. A vegan diet is better at preventing cancer than smoking or consuming cannabis, the onus should be on prevention rather than cure, Attempting to cure a disease you could have prevented is shutting the door after the horse has bolted.
So you hear voices every day of your life?

You are right about the vegan diet. The dope just eases the pain.

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Old 16-06-2015, 09:44 PM   #24
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So you hear voices every day of your life?

You are right about the vegan diet. The dope just eases the pain.
Don't you know cannabinoids have anti-cancer properties? People who still think "pot" is only to relieve the pain of cancer are ignorant. It's not an insult, it's a fact. You can choose to stay ignorant or educate yourself and be knowledgeable. Which one do you like?
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Old 16-06-2015, 10:01 PM   #25
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Don't you know cannabinoids have anti-cancer properties? People who still think "pot" is only to relieve the pain of cancer are ignorant. It's not an insult, it's a fact. You can choose to stay ignorant or educate yourself and be knowledgeable. Which one do you like?
This has credible claims imo, watch 'Run from the Cure -The Rick Simpson story'
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Old 16-06-2015, 10:54 PM   #26
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A spray seems gimmicky. Is it as good as eating a high quality concentrate? I doubt it.
It may seem 'gimmicky' but based on a number of human pharmacokinetic studies its not. There is no way a person could make a high quality concentrate, even if they did it wouldn't work

In one study oral THC bioavailability was reported to be 10−20%. THC plasma (blood) concentrations peaked at 4-6 hours after ingestion. A percentage of the THC was radiolabeled; however, investigators were unable to differentiate labeled THC from its labeled metabolites. Thus, THC concentrations were overestimated. So based on this the half-life would have been 2-3 hours. In another study oral bioavailability was estimated to be 6% and the peak THC concentrations, happened at 1-5 hours, so half-life would have been 30mins to just over 2 hours. Several factors may account for the low oral bioavailability of just 4-20%, including variable absorption, degradation of drug in the stomach, and significant first-pass metabolism to active the active drug (metabolites) and inactive metabolites in the liver.

Sativex is administered sublingually to avoid first-pass metabolism by the liver and the half-life and bioavailability is much, much better. The bioavailability of the rectal route was approximately twice that of the oral route due to higher absorption and lower first-pass metabolism. After application of a dermal (skin) patch, there was a steady-state plasma concentration of THC, and was maintained for at least 48 hours. IV works very well, a bit too much in some cases. Some subjects withdrew from the IV study due to acute paranoia, panic, hypotension, and others due to dislike of THC effects, and other issues. One subject experienced a significant, acute paranoid reaction and was treated with a drug to stop this. THC produced schizophrenia-like positive and negative symptoms and euphoria, and altered aspects of cognitive function. THC produced a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resembled psychoses.
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?
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Old 16-06-2015, 10:58 PM   #27
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This has credible claims imo, watch 'Run from the Cure -The Rick Simpson story'
A pilot clinical study of THC in patients with recurrent glioblastoma multiforme https://en.wikipedia.org/wiki/Glioblastoma_multiforme THC was given intratumoraly and the median survival of the cohort from the beginning of cannabinoid administration was just 24 weeks http://www.nature.com/bjc/journal/v9.../6603236a.html

The IDO pathway that inhibits CD8+ T cells https://en.wikipedia.org/wiki/Cytotoxic_T_cell and enhances the suppressor activity of Tregs https://en.wikipedia.org/wiki/Regulatory_T_cell IDO is expressed in a large proportion of solid tumors including 50 to 90% of glioblastomas (GBM). High IDO expression is correlated with poor prognosis in GBM. 12 patients were required to fully enroll and all were temozolomide-refractory, meaning they were long longer responding to the drug https://en.wikipedia.org/wiki/Temozolomide 6 patients remain on study. Best responses in these previously TMZ-refractory patients to date include SD (stable disease) in 3 patients lasting between 5 and 10 months duration (ongoing) with one patient demonstrating a progressive, ongoing substantial reduction in tumor size, approaching RANO criteria http://radiopaedia.org/articles/rano...r-glioblastoma for PR (partial response) http://meetinglibrary.asco.org/content/152609-156 http://ww.newlinkgenetics.com/assets..._ASCO_2015.pdf

Prolonged Survival In Patients With Recurrent Glioblastoma Multiforme Who Are Treated With Tumor Lysate‐Pulsed Autologous Dendritic Cells http://www.nwbio.com/AACR_poster_prolonged_survival.pdf In 20 Rapid Progressors: The median OS is 15.3 months, most without this kind of treatment live only 8-11 months http://www.nwbio.com/dcvax-technology/

Look at the data, which works better - the drug/immunotherapy or THC?. Also can he back any of his claims up?
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Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

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Old 16-06-2015, 11:03 PM   #28
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Seriously doubt that. Cannabis concentrates are kicking serious ass in the anti-cancer department. But in your view people who have cancer, vegan or not, should not be able to treat it with cannabinoid concentrates because they should have prevented it? A strange opinion of unsound logic if you ask me.
''Cannabis concentrates are kicking serious ass in the anti-cancer department'' There is no data for this, the only study so far is this http://www.nature.com/bjc/journal/v9.../6603236a.html All of them died. However the two studies by GW Pharma in GBM will report their funding by the end of this year. Based on the data they may choose to fund further Phase II studies or they may not
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Old 16-06-2015, 11:07 PM   #29
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Drop hemp seeds, millions of the little buggers all over chernobyl.
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Old 16-06-2015, 11:12 PM   #30
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Drop hemp seeds, millions of the little buggers all over chernobyl.
Great idea grem. Except do it everywhere.
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Old 16-06-2015, 11:44 PM   #31
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''Cannabis concentrates are kicking serious ass in the anti-cancer department'' There is no data for this, the only study so far is this http://www.nature.com/bjc/journal/v9.../6603236a.html All of them died. However the two studies by GW Pharma in GBM will report their funding by the end of this year. Based on the data they may choose to fund further Phase II studies or they may not
There is plenty of data. Unfortunately because of the US government's policies it is mostly anecdotal. Many people are having success treating tumors with "homemade" concentrates. I personally know some of them. Why don't they allow studies on that? There is something called the entourage effect that I believe makes full-spectrum cannabinoid concentrates superior to the 95% THC they used in the study you posted. Why not do a study on CBD or THC and CBD together in various ratios for different ailments...or any combination of the dozens of cannabinoids? Then there is the effect that terpenes have which leads us back to making high-quality extracts of specific Cannabis sativa plants with a known cannabinoid profile. This is what is actually working right now.

Oh, and they injected it?! Try what seems to be working: eating concentrates with a favorable cannabinoid profile. The oral availability is fine trust me. If you need more just eat more. It won't take much. Eating a whole gram in a day is quite a challenge for most people.

Last edited by supertzar; 16-06-2015 at 11:48 PM.
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Old 17-06-2015, 03:44 AM   #32
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There is plenty of data. Unfortunately because of the US government's policies it is mostly anecdotal. Many people are having success treating tumors with "homemade" concentrates. I personally know some of them. Why don't they allow studies on that? There is something called the entourage effect that I believe makes full-spectrum cannabinoid concentrates superior to the 95% THC they used in the study you posted. Why not do a study on CBD or THC and CBD together in various ratios for different ailments...or any combination of the dozens of cannabinoids? Then there is the effect that terpenes have which leads us back to making high-quality extracts of specific Cannabis sativa plants with a known cannabinoid profile. This is what is actually working right now.

Oh, and they injected it?! Try what seems to be working: eating concentrates with a favorable cannabinoid profile. The oral availability is fine trust me. If you need more just eat more. It won't take much. Eating a whole gram in a day is quite a challenge for most people.
All the data that ''proves'' cannabis cures cancer is either In vitro or In vivo, in other words cell dishes or non-humans (rats/mice). Even when its positive it shows very high amounts of THC or CBD is needed to just stop 50% of cancer growth, and most pharma companies want things that inhibit 60% or more of growth before they are willing to start human trials. The biggest problem with anecdotal evidence is that its not necessarily true or reliable, because its based on personal accounts rather than facts or research http://rationalwiki.org/wiki/Anecdotal_evidence https://www.sciencebasedmedicine.org...ased-medicine/ Any one who claims ''cannabis cured my cancer'' should be able to back it up with a case report written by their medical oncologist or family GP, these reports contain full info on any treatments, blood work and much more besides. http://www.davidicke.com/forum/showp...&postcount=270 http://www.davidicke.com/forum/showp...&postcount=276

The reason they used IV and other routes is because oral bioavailability is very low at 4-20%, so around 10% http://www.davidicke.com/forum/showp...0&postcount=15 http://www.davidicke.com/forum/showp...5&postcount=26 In other words if you take 1 gram orally then only 100mg will be absorbed, assuming a 10% availability. So to get a full gram then 10 grams will be needed, and the effects from a dose this high would be bad.

Sativex delivers a near 1:1 ratio of CBD to THC and trials are ongoing with this. Also I could only find one trial for CBD alone https://clinicaltrials.gov/ct2/show/...+cancer&rank=1

The reason why Dr Guzmán PhD chose THC was based on all the pre-clinical work so far. Even when it was given intratumoraly they all still died. The IC50 (how much it takes it stop/inhibit 50%) values in most pre-clinical studies were higher than 10 μM. In his study THC administered to the patients was 20–40 μg at day 1, increasing progressively for 2–5 days up to 80–180 μg day. So they had a lot. As you can see, this is very different from ingesting the oil. It involves directly infusing THC solution at a high concentration directly into the brain cavity where the tumor had been, in the hope of killing off any remaining tumor cells surrounding the cavity. No one generally bothers with intratumoral infusion of a drug unless it requires a very high concentration to work. Mean survival was 24 weeks, and two patients survived approximately a year. The authors try to argue that this is better than would be expected based on other studies and controls, and to claim that some patients responded. I find no convincing evidence of this in the paper, and in a cohort of nine patients though, it's pretty darned hard to conclude this. There is nothing ''earth shattering'' about these results. They could be consistent with an anti-tumor effect, but they could just as easily be consistent with no effect.

The intellectual dishonest of representing this list http://www.collective-evolution.com/...n-cure-cancer/ of studies as evidence that cannabis cures cancer aside, it is a group of moderately interesting papers that suggest that purified cannabinoid receptor drugs can produce reasonable, albeit by no means spectacular, anti-tumor effects in pre-clinical models. As a whole, they suggest that some of these purified cannabinoids, whether naturally occurring, such as THC, CBD, or synthetics, might be worth investigating further. Again, we're talking about pharmacology, isolating active substances and purifying or chemically modifying them to improve their activity and safety profile, not using oil. Cancer Research UK concludes; ''But claims that this body of pre-clinical research is solid 'proof' that cannabis or cannabinoids can cure cancer is highly misleading to patients and their families, and builds a false picture of the state of progress in this area.'' Some of the IC50's have been a tad rather large at 25 μM or more.

Unfortunately, there is also evidence that cannabinoids, under some circumstances, can stimulate cancer cell growth and possibly contribute to tumor progression http://www.ncbi.nlm.nih.gov/pubmed/10861074 http://www.ncbi.nlm.nih.gov/pubmed/15749859 http://www.ncbi.nlm.nih.gov/pubmed/9858061 http://www.ncbi.nlm.nih.gov/pubmed/15026328 They can also have different effects depending on dose and the level of cannabinoid receptors on the tumor cells being treated. For instance, this study http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806825/ suggests that cannabinoids only induce apoptosis https://en.wikipedia.org/wiki/Apoptosis (cell death) in cells that express low levels of receptors that couple to a signaling pathway called ERK1/2 https://en.wikipedia.org/wiki/Extrac...ulated_kinases but don't induce apoptosis in cells that have high levels of receptors because they then couple through a survival pathway known as AKT https://en.wikipedia.org/wiki/Protein_kinase_B Interestingly, cannabinoids also seem able to induce cell death through pathways that don't involve cannabinoid receptors. In other words, it's complicated, because cancer is complicated, and cancer drugs tend to work only against certain cancers. If cannabinoids do have anticancer effects in humans, it will likely only be against certain cancers, most likely combined with existing treatments. We also know from the pre-clinical work that has been done that it will take purified THC and/or CBD and/or synthetic cannabinoids to produce even the modest effects observed thus far, effects that are too modest to expect cannabinoids to be any sort of cure for cancer on their own. Using the oil just isn't going to cut it.

If they do find their way into the routine clinical treatment of cancer, it will be through rigorous pharmacological studies and rigorous clinical trials, the latter of which, in particular, are painfully lacking. There are very few, and suggests that there is not much interest in even synthetic cannabinoids as a treatment for cancer. After all, there are so many other promising avenues that a class of drugs that show the modest effects that the cannabinoids do, just don’t excite researchers that much.
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Old 17-06-2015, 03:50 AM   #33
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All the data that ''proves'' cannabis cures cancer is either In vitro or In vivo, in other words cell dishes or non-humans (rats/mice).
That is the problem. Human studies are banned. It's hard to even get permission to study rats and petri dishes. You have to look at the many people who are having success outside of the government lockdown on cannabinoids. I would say it is pretty spectacular to have your tumors disappear by eating a concentrate made by someone you know.

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Old 17-06-2015, 07:38 AM   #34
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de-criminalize of course - I wouldn't use it though - don't feel the need.

If you can't do as you please with your own body, then the only thing you can be is a slave...
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Old 17-06-2015, 05:09 PM   #35
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Let's see who says no!
Me says no

Too many people are self medicating on drugs because they have other problems and one thing leads to another.

I have no trouble with a £10 fine if caught because thats one way to keep the grobby little hands of the government off it and cuts the profit for drug companies.

What i don't agree with one bit is the USA putting people in jail for 2 years to feed the prison for profit system because a little bit of weed and think that shareholders of these jails need to have there heads removed.

I don't have answers that fit perfect but nor does the other side and in case you is thinking, yes me has enjoyed the pleasures when i was younger, did me no harm.
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Old 17-06-2015, 05:20 PM   #36
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Me says no

Too many people are self medicating on drugs because they have other problems and one thing leads to another.

I have no trouble with a £10 fine if caught because thats one way to keep the grobby little hands of the government off it and cuts the profit for drug companies.

What i don't agree with one bit is the USA putting people in jail for 2 years to feed the prison for profit system because a little bit of weed and think that shareholders of these jails need to have there heads removed.

I don't have answers that fit perfect but nor does the other side and in case you is thinking, yes me has enjoyed the pleasures when i was younger, did me no harm.
Do you have any idea how many people depend on the herb to help with serious illnesses? Little kids with hundreds of seizures a week are having no seizures because of eating concentrates. Are you sure you want to make their parents seek medicine on the black market? Why should there be a punishment for having the safest, most widely effective medicine on the planet? Definitely removing all laws against Cannabis sativa is the only sane policy. It is so beneficial in so many ways. There is nothing else like it.

Last edited by supertzar; 17-06-2015 at 05:23 PM.
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Old 17-06-2015, 05:22 PM   #37
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If you can't do as you please with your own body, then the only thing you can be is a slave...
if i was to smoke then it would kill me because my heart stops when I smoke pot and I have already had a heart attack so would you like to pick up the medical bill if I become brain dead and the govenment keeps me alive just so they can bill the tax payers.

No didn't think so.

What about Angle dust that makes people strong and aggressive

Our police are all fucked up as it is because lots of them are taking steriods so lets not pretend is just about being a slave, slaves also have rules between themselves.

You make a good argument but it's not quite so easy as that
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Old 17-06-2015, 05:34 PM   #38
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Do you have any idea how many people depend on the herb to help with serious illnesses?
People kill themselves because of cyber insults and the govenment wants to use that an an excuse to make us all use an ID so they can spy on us and remove our freedom of speech.

0.0001% of the population cannot be used as an excuse by our government to change the law and the same applies to us.

if we had a vote on this then the population would be split 50/50 not that this matters to the government when 99% vote for one thing and get another.

People depend on and get Morphine when needed so me is OK with weed on licence if needs be but i don't think that weed is a cure in any way for cancer or makes the best rope money can buy.

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There is nothing else like it.
They say the same about coke and sex, i would not know but we do in this case need laws "we the people" can agree on and i am not sure it would be a big yes if put to the vote

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Old 17-06-2015, 05:47 PM   #39
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if i was to smoke then it would kill me because my heart stops when I smoke pot and I have already had a heart attack so would you like to pick up the medical bill if I become brain dead and the govenment keeps me alive just so they can bill the tax payers.

No didn't think so.

What about Angle dust that makes people strong and aggressive

Our police are all fucked up as it is because lots of them are taking steriods so lets not pretend is just about being a slave, slaves also have rules between themselves.

You make a good argument but it's not quite so easy as that
Yeah right....
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Old 17-06-2015, 05:50 PM   #40
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Cotton money played a bit part in putting down hemp and criminalising it.
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