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Old 03-03-2017, 05:15 AM   #4
dumbcritic
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I'm guessing you mean methylene blue? I know it was being investigated http://www.sciencedirect.com/science...72100005000979 as a possible activating agent that is used in photodynamic https://en.wikipedia.org/wiki/Photodynamic_therapy and sonodynamic therapy. But there isn't enough good evidence for it as an anticancer drug in us. As for sonodynamic therapy then it lacks independent evidence of effect and most of the case reports have been published in low impact factor journals, including those specialising in "alternative" therapies which is a shame http://journals.sagepub.com/doi/pdf/...34735409343693

Dynavax has developed an inhaled drug (DV281), delivered by a nebulizer, and which is expected to enter clinical trials for non-small cell lung carcinoma (NSCLC), in combination with anti-PD-1 therapy, in the second half of this year http://www.abstractsonline.com/pp8/#...sentation/6078

Another drug is 3-bromopyruvate which when aerosolized significantly decreased tumour multiplicity and load by 49% and 80%, respectively, depending on the dosage used. Interestingly, the efficacy of it did not accompany any toxicity in the lungs or liver indicating that it is a safe route of administering this compound http://cancerpreventionresearch.aacr...t/5/5/717.long Sadly this case was never published http://www.prnewswire.com/news-relea...277467361.html For an additive or synergistic effect then it could be combined with sodium citrate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750747/ http://www.sciencedirect.com/science...06291X16307082
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Last edited by dumbcritic; 03-03-2017 at 05:37 AM.
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