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Old 16-01-2019, 12:05 AM   #512
dumbcritic
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Quote:
Originally Posted by supertzar View Post
Dumcritic's preferred medicines aren't too toxic but apricot seeds are the devil(!)
Any pharma company testing that would have simply discarded the substance due to it being useless and killing healthy cells better than cancer cells. Since the quacks have gotten a hold on it, I know they never, ever, discard a treatment, no matter useless, or even harmful it is.

In the CheckMate 017 trial Docetaxel (a type of chemo) was tested against Nivolumab (a type of immunotherapy) in those with non-small cell lung cancer. Forty-two percent treated with the immunotherapy are alive at 1 year vs. 24% treated with chemo. At year two its 30% vs. 10%. Not only that, but Nivolumab had a better response rate (more tumour shrinkage) and less serious/life-threatening adverse events (7% vs. 55%) https://www.nejm.org/doi/10.1056/NEJMoa1504627

Around 16% in the Nivolumab arm lived for more than five years, about four times what is typically expected for patients treated with Docetaxel http://ascopubs.org/doi/full/10.1200/JCO.2017.77.0412

So yes, there are risks with Nivolumab, but the benefits on the whole outweigh them. The key is now building on this and trying to improve survival. I know some early human data on an inhaled immunotherapy combined with Nivolumab will be presented in the next few months at a major medical meeting (likely AACR). Preclinical wise the two had a synergistic effect and most mice were cured http://cancerres.aacrjournals.org/content/78/17/4943
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''Chlorine is a deadly poison gas employed on European battlefields in World War I. Sodium is a corrosive metal which burns upon contact with water. Together they make a placid and unpoisonous material, table salt. Why each of these substances has the properties it does is a subject called chemistry'' - Carl Sagan

Why is it that the loudest critics of ''Big Pharma'' are Big Placebo?

Last edited by dumbcritic; 16-01-2019 at 01:19 AM.
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