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Old 15-12-2017, 11:56 AM   #20
dumbcritic
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Originally Posted by the tealady View Post
I have heard about the theory.
You collect tumour and blood samples and go through a long process to create the vaccine (some of which is explained in the following link) https://www.fiercebiotech.com/sponso...identification This is needed to try and identify the patients' own neoantigens, or newly formed antigens that are often found in cancer cells but usually haven't been recognised by the immune system. The contents of the vaccines are taken up by antigen presenting cells and educate certain T-cells to recognise and attack specific targets on the cancer cells and thereby kill them. What makes these an attractive target is that they (neoantigens) are seen as ''foreign'' to the immune system so there should be no tolerance (central or peripheral). Responses to them also drive checkpoint inhibitor efficacy http://science.sciencemag.org/content/348/6230/69.long

However a number of problems need to be overcome. The current in silico approaches have limited ability to predict the right neoantigens for both CD4+ (~5%) http://journals.plos.org/ploscompbio...l.pcbi.1000048 and CD8+ (~20%) T-cells http://www.cell.com/immunity/fulltex...613(17)30042-0 The former help expand and enhance the function of CD8+ T-cells, mediate tumour-associated macrophage repolarisation, have antiangiogenic effects and other antitumour immune mechanisms http://www.cancerletters.info/articl...022-8/fulltext
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Last edited by dumbcritic; 15-12-2017 at 12:05 PM.
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